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p53 tumor suppressor gene: a critical molecular target for UV induction and prevention of skin cancer.

Photochem Photobiol 2008 Jan-Feb;84(1):55-62

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The relationship between exposure to UV radiation and development of skin cancer has been well established. Several studies have shown that UVB induces unique mutations (C-->T and CC-->TT transitions) in the p53 tumor suppressor gene that are not commonly induced by other carcinogens. Our studies have demonstrated that UV-induced mouse skin cancers contain p53 mutations at a high frequency and that these mutations can be detected in UV-irradiated mouse skin well before the appearance of skin tumors. This observation suggested that it might be possible to use p53 mutations as a biologic endpoint for testing the efficacy of sunscreens in photoprotection studies. Indeed, application of SPF 15 sunscreens to mouse skin before each UVB irradiation resulted in reduction in the number of p53 mutations. Because p53 mutations represent an early essential step in photocarcinogenesis, these results imply that inhibition of this event may protect against skin cancer development. This hypothesis was confirmed by our finding that sunscreens used in p53 mutation inhibition experiments also protected mice against UVB-induced skin cancer.

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March 2008
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Cell Rep 2021 Feb;34(8):108772

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Evidence regarding intraductal papillary neoplasm of the bile duct (IPNB) as a type of precancerous lesion of cholangiocarcinoma is limited. Moreover, a reproducible in vivo model is lacking, and IPNB pathogenesis remains unclear. Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation. Read More

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Validation of oral brushing as a non-invasive technique for the identification of feline oral squamous cell carcinoma by DNA methylation and TP53 mutation analysis.

Vet Comp Oncol 2021 Feb 23. Epub 2021 Feb 23.

Department of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna, Italy.

Feline oral squamous cell carcinoma (FOSCC) is a frequent and progressively invasive tumour. Early lesions are difficult to recognize based on the sole clinical examination and may be misinterpreted as non-neoplastic. Mutations of TP53 and epigenetic alterations of specific genes are present in FOSCC and may be early detected. Read More

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Blood 2021 Feb 23. Epub 2021 Feb 23.

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.

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Loss of coiled-coil protein Cep55 impairs neural stem cell abscission and results in p53-dependent apoptosis in developing cortex.

J Neurosci 2021 Feb 22. Epub 2021 Feb 22.

Department of Cell Biology

To build the brain, embryonic neural stem cells (NSCs) tightly regulate their cell divisions, undergoing a polarized form of cytokinesis that is poorly understood. Cytokinetic abscission is mediated by the midbody to sever the daughter cells at the apical membrane. In cell lines, the coiled-coil protein Cep55 was reported to be required for abscission. Read More

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Genetic and molecular subtype heterogeneity in newly diagnosed early- and advanced-stage endometrial cancer.

Gynecol Oncol 2021 Feb 20. Epub 2021 Feb 20.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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