Anti-inflammatory effect of meloxicam on experimental vasospasm in the rat femoral artery.

Authors:
Prof Tayfun Hakan, MD
Prof Tayfun Hakan, MD
Fatih Sultan Mehmet Training and Research Hospital
Prof. Dr.
Ataşehir, İstanbul | Turkey

J Clin Neurosci 2008 Jan 26;15(1):55-9. Epub 2007 Nov 26.

Department of Neurosurgery, Haydarpaşa Numune Teaching and Research Hospital, Istanbul, Turkey.

Cerebral vasospasm influences morbidity and mortality following subarachnoid haemorrhage (SAH). Inflammation is believed to play a role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. We investigated the effect of meloxicam on a rat femoral artery vasospasm model using the radial wall thickness and cross-sectional lumen area as parameters under light, scanning and transmission electron microscopy examination. Rats were randomly separated into SAH, SAH+ meloxicam and control groups. Rats in the SAH+ meloxicam group were given meloxicam at 2 mg/kg daily for 7 days. Femoral arteries were examined by light microscopy and scanning and transmission electron microscopy, and for morphometric analysis. A statistically significant difference (p<0.001) was detected between the SAH and SAH+ meloxicam groups. Meloxicam treatment reduced ultrastructural and morphometric vasospastic changes. These findings support the hypothesis that inflammation may play a role in the pathophysiologyical pathways of post-haemorrhagic cerebral vasospasm.

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http://dx.doi.org/10.1016/j.jocn.2006.10.010DOI Listing
January 2008
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