Synthesis of novel spirostanic saponins and their cytotoxic activity.

Authors:
Juan C Hernandez
Juan C Hernandez
State University of New York at Buffalo
United States
Francisco Leon
Francisco Leon
National Institutes of Health
United States
Ignacio Brouard
Ignacio Brouard
University of Pennsylvania
United States
Fernando Torres
Fernando Torres
University of Texas Southwestern Medical Center
United States
Sara Rubio
Sara Rubio
University of Las Palmas de Gran Canaria
Jose Quintana
Jose Quintana
Hospital Galdakao-Usansolo (Osakidetza)-Red de Investigación en Servicios de Salud en Enfermedades Crónicas
Spain
Francisco Estevez
Francisco Estevez
Juan Canalejo Hospital
Spain
Jaime Bermejo
Jaime Bermejo
Università di Ferrara
Italy

Bioorg Med Chem 2008 Feb 4;16(4):2063-76. Epub 2007 Nov 4.

Instituto de Productos Naturales y Agrobiología-C.S.I.C., Antonio González, Av. Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain.

This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S09680896070095
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2007.10.089DOI Listing

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February 2008
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