The activating killer cell immunoglobulin-like receptors as important determinants of acute graft-versus host disease in hematopoietic stem cell transplantation for acute myelogenous leukemia.

Transplantation 2007 Nov;84(9):1082-91

Catholic Hemopoietic Stem Cell Transplantation Center, Catholic University of Korea College of Medicine, Seoul, Korea.

Background: We investigated the influence of killer cell immunoglobulin-like receptor (KIR) genes, based on the genotypes of inhibitory or activating KIR, in stem cell recipients with acute myelogenous leukemia and their human leukocyte antigen-matched sibling donors on acute graft-versus host disease (GVHD) after hematopoietic stem cell transplantation.

Methods: We studied 53 consecutive donor-recipient pairs to determine the impact of KIR genotypes and their bidirectional KIR interactions.

Results: All activating KIR genes in donors were important factors for determining outcome in a manner distinctive for each gene studied. Specifically, the 2DS2 gene and the 2DS4*003 allele were closely correlated with acute GVHD. The 2DS1 gene was associated with a better long-term survival, even if present only in the donor and not the recipient. The 2DS3-2DS5 dual genes were more often involved in a variety of transplant-related complications.

Conclusions: In conclusion, these factors may help predict transplant outcomes and aid in our understanding of immunogenetic specificity.

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.tp.0000285918.72930.35DOI Listing
November 2007
2 Reads
6 Citations
3.830 Impact Factor

Publication Analysis

Top Keywords

stem cell
12
hematopoietic stem
8
graft-versus host
8
host disease
8
myelogenous leukemia
8
activating kir
8
kir genes
8
acute graft-versus
8
acute myelogenous
8
killer cell
8
cell immunoglobulin-like
8
cell
5
kir
5
acute
5
gvhd hematopoietic
4
disease gvhd
4
conclusion factors
4
transplantationmethods studied
4
2ds2 gene
4
cell transplantationmethods
4

Similar Publications