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Horm Behav 2021 Feb 26:104952. Epub 2021 Feb 26.

Department of Physiology and Pathology, School of Dentistry, São Paulo State University - UNESP, Araraquara, SP, Brazil. Electronic address:

Spontaneously hypertensive rats (SHRs) ingest more NaCl than normotensive strains. Here we investigated NaCl intake and taste reactivity in adult male SHRs and normotensive Holtzman rats treated or not with AT1 receptor antagonist centrally in euhydrated condition and after fluid depletion. Taste reactivity was measured by the number of orofacial expressions to intra-oral infusions of 0. Read More

J Alzheimers Dis 2021 Feb 23. Epub 2021 Feb 23.

Baycrest Health Sciences, Toronto, Ontario, Canada.

Background: In 2015, a patient in hospice with Alzheimer's disease (AD) was treated with ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech, movement, and appetite was observed. These improvements were so momentous that she was discharged from the hospice to a long-term care home. Read More

Trials 2021 Feb 23;22(1):159. Epub 2021 Feb 23.

National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.

Background: Atypical antipsychotic medications, which are effective for the treatment of schizophrenia and bipolar disorder, are associated with features of metabolic syndrome, such as weight gain, hyperglycemia, dyslipidemia, and insulin resistance. Although there are a few studies on the effects of dietary fiber or probiotics on weight loss in obese people, no published trials have reported the efficacy of dietary fiber and probiotics on reducing atypical antipsychotic-induced weight gain.

Methods: For this 12-week randomized, double-blind, placebo-controlled study, 100 patients with a weight gain of more than 10% after taking atypical antipsychotic medications were recruited. Read More

Eur J Nutr 2021 Feb 23. Epub 2021 Feb 23.

School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, LE11 3TU, UK.

Purpose: We previously observed increased energy intake (EI) at the meal before planned afternoon exercise, but the proximity of the meal to exercise might have reduced the scale of the pre-exercise anticipatory eating. Therefore, this study examined EI in the 24 h before fasted morning exercise.

Methods: Fourteen males, experienced with gym-based aerobic exercise (age 25 ± 5 years, BMI 23. Read More

Case Rep Oncol 2021 Jan-Apr;14(1):1-7. Epub 2021 Jan 11.

First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Pembrolizumab is an anti-programmed cell death protein-1 antibody that is mainly used for the treatment of non-small cell lung cancer (NSCLC). Immune-related adverse events can be caused by immune checkpoint inhibitors; however, few case reports evaluate the prognosis of patients with NSCLC with late-onset immune-related adverse events. In this case, a 63-year-old man with stage IVA lung adenocarcinoma received pembrolizumab as first-line therapy and achieved a complete response. Read More