Case report: severe gastrointestinal inflammation and persistent HHV-6B infection in a paediatric cancer patient.

Herpes 2007 Sep;14(2):41-4

Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University of Düsseldorf, Germany.

Lymphotropic herpesviruses such as human herpesvirus type 6 (HHV-6) have enhanced pathogenicity in some immunocompromised hosts, such as transplant recipients and HIV-infected patients. The clinical relevance of HHV-6 infections in cancer patients undergoing conventional cytotoxic therapy is undetermined, however. Here we report on a 10-month-old boy with an anaplastic astrocytoma, who acquired an HHV-6 variant B infection during chemotherapy. HHV-6B infection caused or triggered severe gastrointestinal inflammation with intractable diarrhoea and failure to thrive over several months. The clinical symptoms were associated with pronounced (CD4) lymphopenia and a marked increase in serum immunoglobulin A levels. After unsuccessful therapy with ganciclovir and foscarnet, combined antiviral and anti-inflammatory treatment with cidofovir and prednisolone controlled the HHV-6 infection and enabled resolution of clinical symptoms.

Download full-text PDF

Source
September 2007

Publication Analysis

Top Keywords

hhv-6b infection
8
clinical symptoms
8
severe gastrointestinal
8
gastrointestinal inflammation
8
chemotherapy hhv-6b
4
infection caused
4
thrive months
4
months clinical
4
infection chemotherapy
4
caused triggered
4
triggered severe
4
failure thrive
4
intractable diarrhoea
4
variant infection
4
inflammation intractable
4
diarrhoea failure
4
astrocytoma acquired
4
conventional cytotoxic
4
cytotoxic therapy
4
undergoing conventional
4

Similar Publications