J Am Chem Soc 2007 Oct 29;129(42):12592-3. Epub 2007 Sep 29.
Laboratoire d'Optique et Biosciences and Laboratoire de Physique de la Matière Condensée, Ecole Polytechnique, CNRS, 91128 Palaiseau, France, and INSERM U696, 91128, Palaiseau, France.
Eur J Med Chem 2021 Apr 10;219:113446. Epub 2021 Apr 10.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States. Electronic address:
ATPases Associated with Diverse Cellular Activity (AAA ATPase) are essential enzymes found in all organisms. They are involved in various processes such as DNA replication, protein degradation, membrane fusion, microtubule serving, peroxisome biogenesis, signal transduction, and the regulation of gene expression. Due to the importance of AAA ATPases, several researchers identified and developed small-molecule inhibitors against these enzymes. Read More
Biochim Biophys Acta Mol Cell Res 2021 Apr 16:119046. Epub 2021 Apr 16.
Institute of Biochemistry, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address:
The neuropeptide 26RFa plays important roles in the regulation of many physiological functions. 26RFa has been recognized as an endogenous ligand for receptor GPR103. In the present study, we demonstrate that GPR103 dually couples to Gαq and Gαi/o proteins. Read More
FEBS J 2021 Apr;288(8):2461-2489
Department of Pharmaceutical Chemistry, Philipps-University Marburg, Germany.
G protein-coupled receptors (GPCRs) play critical roles in the regulation of human physiology in response to a wide array of different extracellular stimuli and thus represent one of the largest groups of therapeutic drug targets. Recent advances in the structural characterization of GPCRs in different conformations and in complex with G proteins and arrestins have provided important insights into the mechanism and function of GPCRs. However, in order to truly understand the molecular basis of the functional versatility of GPCRs, the structural snapshots obtained by X-ray crystallography or cryo-EM need to be complimented with information about the conformational dynamics of receptors and their signaling complexes. Read More
J Biomol Struct Dyn 2021 Apr 19:1-13. Epub 2021 Apr 19.
Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College, University of Delhi, Delhi, India.
Plasmepsin V (Plm V) is an essential aspartic protease required for survival of the malaria parasite, . Plm V is required for cleaving the PEXEL motifs of many proteins and its inhibition leads to a knockout effect, indicating its suitability as potential drug target. To decipher new inhibitors of Plm V, molecular docking of four HIV-1 protease inhibitors active against PlmV was performed on Glide module of Schrödinger suite that supported saquinavir as a lead drug, and therefore, selected as a control. Read More
Methods Enzymol 2021 18;650:215-236. Epub 2021 Feb 18.
Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland. Electronic address:
Rare-earth elements (REEs) were recently discovered to be biologically significant. The finding was originally made with the methanol dehydrogenase XoxF, which depends on REEs for its activity, and reports of lanthanide-utilizing bacteria have since expanded. Environmental proteomics allows the identification of proteins specifically induced by the presence of lanthanides or can provide insights into the preferred use of lanthanide-dependent and -independent isoenzymes, for example. Read More