The ribosome filter redux.

Cell Cycle 2007 Sep 29;6(18):2246-51. Epub 2007 Jun 29.

Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.

The ribosome filter hypothesis postulates that ribosomes are not simply translation machines but also function as regulatory elements that differentially affect or filter the translation of particular mRNAs. On the basis of new information, we take the opportunity here to review the ribosome filter hypothesis, suggest specific mechanisms of action, and discuss recent examples from the literature that support it.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930609PMC
http://dx.doi.org/10.4161/cc.6.18.4739DOI Listing
September 2007
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