Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFalpha.

J Huazhong Univ Sci Technolog Med Sci 2007 Aug;27(4):354-7

College of Life Science and Technology, Huazhong Universty of Science and Technology, Wuhan 430074, China.

Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFalpha was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFalpha was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFalpha might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFalpha can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.

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http://dx.doi.org/10.1007/s11596-007-0402-9DOI Listing
August 2007
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