Beringian standstill and spread of Native American founders.

PLoS One 2007 Sep 5;2(9):e829. Epub 2007 Sep 5.

Department of Evolutionary Biology, University of Tartu, Estonian Biocentre, Tartu, Estonia.

Native Americans derive from a small number of Asian founders who likely arrived to the Americas via Beringia. However, additional details about the initial colonization of the Americas remain unclear. To investigate the pioneering phase in the Americas we analyzed a total of 623 complete mtDNAs from the Americas and Asia, including 20 new complete mtDNAs from the Americas and seven from Asia. This sequence data was used to direct high-resolution genotyping from 20 American and 26 Asian populations. Here we describe more genetic diversity within the founder population than was previously reported. The newly resolved phylogenetic structure suggests that ancestors of Native Americans paused when they reached Beringia, during which time New World founder lineages differentiated from their Asian sister-clades. This pause in movement was followed by a swift migration southward that distributed the founder types all the way to South America. The data also suggest more recent bi-directional gene flow between Siberia and the North American Arctic.

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000829PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952074PMC
September 2007
48 Reads

Publication Analysis

Top Keywords

americas asia
8
mtdnas americas
8
complete mtdnas
8
native americans
8
americas
5
ancestors native
4
population reported
4
founder population
4
diversity founder
4
reported newly
4
newly resolved
4
structure suggests
4
genetic diversity
4
phylogenetic structure
4
resolved phylogenetic
4
suggests ancestors
4
asian populations
4
sequence data
4
asia sequence
4
including complete
4

References

(Supplied by CrossRef)
Asian affinities and contiental radiation of the four founding Native American mtDNAs.
A Torroni et al.
Am J Hum Genet 1993
Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.
TG Schurr et al.
Am J Hum Genet 1990
Origin and evolution of Native American mtDNA variation: a reappraisal.
P Forster et al.
Am J Hum Genet 1996
Founder mitochondrial haplotypes in Amerindian populations.
G Bailliet et al.
Am J Hum Genet 1994
Genetic and linguistic differentiation in the Americas.
RH Ward et al.
Proc Natl Acad Sci U.S.A. 1993
mtDNA sequences suggest a recent evolutionary divergence for Beringian and northern North American populations.
GF Shields et al.
Am J Hum Genet 1993

Similar Publications