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Epigenomics 2021 Apr 21. Epub 2021 Apr 21.

Department of Medicine, Università degli Studi di Udine. P.le Kolbe 4, Udine, 33100, Italy.

In the breast, the pleiotropic epigenetic regulator HDAC7 can influence stemness. The authors used MCF10 cells knocked-out for HDAC7 to explore the contribution of HDAC7 to IGF1 signaling. HDAC7 buffers H3K27ac levels at the IGFBP6 and IGFBP7 genomic loci and influences their expression. Read More

JCI Insight 2021 Apr 13. Epub 2021 Apr 13.

Department of Pediatrics, Children's Hospital of Philadelphia Research Institute, Philadelphia, United States of America.

Retinoic acid (RA) signaling is essential for enteric nervous system (ENS) development since vitamin A deficiency or mutations in RA signaling profoundly reduce bowel colonization by ENS precursors. These RA effects could occur because of RA activity within the ENS lineage or via RA activity in other cell types. To define cell-autonomous roles for retinoid signaling within the ENS lineage at distinct developmental time points, we activated a potent floxed dominant-negative RA receptor α (RarαDN) in the ENS using diverse CRE recombinase-expressing mouse lines. Read More

Biochemistry (Mosc) 2021 Feb;86(2):217-229

Blokhin National Medical Research Center of Oncology, Moscow, 115478, Russia.

Retinoic acid (RA) binding proteins, CRABP1 and CRABP2, are molecular chaperones that mediate intracellular activity of RA, the key promoter of cell differentiation with tumor suppressor activity. One of the main functions of CRABP2 is delivery and transfer of RA to the nuclear receptors RAR/RXR, which leads to activation of the transcription of a wide range of retinoid-responsive genes. The functions of CRABP1 are less studied but are apparently associated with sequestration of RA in cytoplasm and limitation of its transcriptional activity, suggesting involvement of this protein in the development of RA resistance. Read More

Front Vet Sci 2021 19;8:619759. Epub 2021 Mar 19.

Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.

Research has been undertaken to understand the host immune response to infection because of the importance of the disease in the public health field and the clinical field. However, the previous mechanisms governing this infection have not been elucidated. Therefore, models, which mimic the infection route using a canine epithelial cell line, D17, and a canine macrophage, DH82, were established to determine these mechanisms by performing an analysis of the transcriptomes in the cells. Read More

Nutrients 2021 Mar 12;13(3). Epub 2021 Mar 12.

Paprika Bioanalytics BT, 4002 Debrecen, Hungary.

Vitamin A is a family of derivatives synthesized from carotenoids acquired from the diet and can be converted in animals to bioactive forms essential for life. Vitamin A1 (all--retinol/ATROL) and provitamin A1 (all--β,β-carotene/ATBC) are precursors of all--retinoic acid acting as a ligand for the retinoic acid receptors. The contribution of ATROL and ATBC to formation of 9--13,14-dihydroretinoic acid (9CDHRA), the only endogenous retinoid acting as retinoid X receptor (RXR) ligand, remains unknown. Read More