An improved synthesis for the (Z)-14-methyl-9-pentadecenoic acid and its topoisomerase I inhibitory activity.

ARKIVOC 2007 ;2007(viii):49-57

An improved synthesis for the (Z)-14-methyl-9-pentadecenoic acid was developed based on the appropriate use of (trimethylsilyl)acetylene as the key reagent in the synthesis. The reported synthesis started with commercially available 8-bromo-1-octanol and furnished the desired acid in seven steps and in a 16% overall yield, a significant improvement over the previous reported synthesis for this fatty acid. The synthesis reported herein afforded sufficient amounts to study the acid topoisomerase I inhibitory potential and it was found that the title acid inhibits the human placenta DNA topoisomerase I enzyme at concentrations of 500 μM.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939943PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
January 2007
8 Reads

Publication Analysis

Top Keywords

acid topoisomerase
8
reported synthesis
8
synthesis reported
8
z-14-methyl-9-pentadecenoic acid
8
topoisomerase inhibitory
8
synthesis z-14-methyl-9-pentadecenoic
8
improved synthesis
8
acid
6
synthesis
5
steps 16%
4
inhibits human
4
16% yield
4
yield improvement
4
acid steps
4
desired acid
4
furnished desired
4
commercially 8-bromo-1-octanol
4
human placenta
4
8-bromo-1-octanol furnished
4
acid inhibits
4

Similar Publications