Presence of talc in pelvic lymph nodes of a woman with ovarian cancer and long-term genital exposure to cosmetic talc.

Obstet Gynecol 2007 Aug;110(2 Pt 2):498-501

Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Background: Although epidemiologic studies suggest talc use may increase ovarian cancer risk, there is no proof that talc used externally reaches the pelvis.

Case: A 68-year-old woman with stage III ovarian papillary serous carcinoma revealed she had used talc daily for 30 years to powder her genital area. Examination of her pelvic lymph nodes under polarized light microscopy showed diffuse areas of birefringence compatible with talc, confirmed by scanning electron microscopy and X-ray spectroscopy.

Conclusion: This description of talc in pelvic lymph nodes of a woman with ovarian cancer and decades of exposure to talc may prompt new studies and offer new insights into the biologic basis for the consistent, but debated, association between talc use and ovarian cancer.

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.AOG.0000262902.80861.a0DOI Listing
August 2007
324 Reads

Publication Analysis

Top Keywords

ovarian cancer
16
pelvic lymph
12
lymph nodes
12
woman ovarian
8
nodes woman
8
talc
8
talc pelvic
8
ovarian
5
talc daily
4
talc prompt
4
revealed talc
4
daily years
4
years powder
4
decades exposure
4
powder genital
4
carcinoma revealed
4
exposure talc
4
serous carcinoma
4
stage iii
4
offer insights
4

Similar Publications