Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Presence of talc in pelvic lymph nodes of a woman with ovarian cancer and long-term genital exposure to cosmetic talc.

Authors:
Daniel W Cramer William R Welch Ross S Berkowitz John J Godleski

Obstet Gynecol 2007 Aug;110(2 Pt 2):498-501

Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Background: Although epidemiologic studies suggest talc use may increase ovarian cancer risk, there is no proof that talc used externally reaches the pelvis.

Case: A 68-year-old woman with stage III ovarian papillary serous carcinoma revealed she had used talc daily for 30 years to powder her genital area. Examination of her pelvic lymph nodes under polarized light microscopy showed diffuse areas of birefringence compatible with talc, confirmed by scanning electron microscopy and X-ray spectroscopy.

Conclusion: This description of talc in pelvic lymph nodes of a woman with ovarian cancer and decades of exposure to talc may prompt new studies and offer new insights into the biologic basis for the consistent, but debated, association between talc use and ovarian cancer.

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.AOG.0000262902.80861.a0DOI Listing
August 2007

Publication Analysis

Top Keywords

ovarian cancer
16
pelvic lymph
12
lymph nodes
12
woman ovarian
8
nodes woman
8
talc
8
talc pelvic
8
ovarian
5
talc daily
4
talc prompt
4
revealed talc
4
daily years
4
years powder
4
decades exposure
4
powder genital
4
carcinoma revealed
4
exposure talc
4
serous carcinoma
4
stage iii
4
offer insights
4

Altmetric Statistics


Show full details
2 Total Shares
1 Facebook Pages
1 News Outlets
2 Citations

Similar Publications

The role of gonadotropin-releasing hormone agonists in female fertility preservation.

Authors:
Jae Hoon Lee Young Sik Choi

Clin Exp Reprod Med 2021 Mar 18;48(1):11-26. Epub 2021 Feb 18.

Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Advances in anticancer treatments have resulted in increasing survival rates among cancer patients. Accordingly, the quality of life after treatment, particularly the preservation of fertility, has gradually emerged as an essential consideration. Cryopreservation of embryos or unfertilized oocytes has been considered as the standard method of fertility preservation among young women facing gonadotoxic chemotherapy. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Early life exposure to tobacco smoke and ovarian cancer risk in adulthood.

Authors:
Tianyi Wang Mary K Townsend Christine Vinci Danielle E Jake-Schoffman Shelley S Tworoger

Int J Epidemiol 2021 Feb 27. Epub 2021 Feb 27.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Background: Ovarian cancer risk in adulthood may be affected by early life exposure to tobacco smoke. We investigated this relationship in two large prospective cohorts, the Nurses' Health Study (NHS) and NHSII.

Methods: In total, analyses included 110 305 NHS participants (1976-2016) and 112 859 NHSII participants (1989-2017). Read More

View Article and Full-Text PDF
February 2021
Similar Publications

How to use liquid biopsies to treat patients with cancer.

Authors:
L De Mattos-Arruda G Siravegna

ESMO Open 2021 Feb 26;6(2):100060. Epub 2021 Feb 26.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA.

Precision medicine is now pivotal to design patients' specific treatment strategies with the aim of prolonging progression and overall survival. In this regard, invasive tumor tissue testing has so far been the golden standard for making cancer diagnosis, but has limitations. Cell-free tumor DNA (ctDNA), a form of liquid biopsy, is a noninvasive biomarker that can be isolated from patients' blood and other biofluids. Read More

View Article and Full-Text PDF
February 2021
Similar Publications

Gene Sequencing for Pathogenic Variants Among Adults With Breast and Ovarian Cancer in the Caribbean.

Authors:
Sophia H L George Talia Donenberg Cheryl Alexis Vincent DeGennaro Hedda Dyer Sook Yin Jameel Ali Raleigh Butler Sheray N Chin DuVaughn Curling Dwight Lowe John Lunn Theodore Turnquest Gilian Wharfe Danielle Cerbon Priscila Barreto-Coelho Matthew P Schlumbrecht Mohammad R Akbari Steven A Narod Judith E Hurley

JAMA Netw Open 2021 Mar 1;4(3):e210307. Epub 2021 Mar 1.

Sylvester Comprehensive Cancer Center, Miami, Florida.

Importance: Rates of breast and ovarian cancer are high in the Caribbean; however, to date, few published data quantify the prevalence of inherited cancer in the Caribbean population.

Objective: To determine whether deleterious variants in genes that characterize the hereditary breast and ovarian cancer syndrome are associated with the development of breast and ovarian cancer in the English- and Creole-speaking Caribbean populations.

Design, Setting, And Participants: This multisite genetic association study used data from germline genetic test results between June 2010 and June 2018 in the Bahamas, Cayman Islands, Barbados, Dominica, Jamaica, Haiti, and Trinidad and Tobago. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Perspectives on PARP inhibitors as pharmacotherapeutic strategies for breast cancer.

Authors:
Sun Young Oh Shafia Rahman Joseph A Sparano

Expert Opin Pharmacother 2021 Mar 1. Epub 2021 Mar 1.

Montefiore Medical Center, Montefiore Einstein Center for Cancer Care, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, NY.

IntroductionApproximately 10% of all breast cancer cases occur in individuals who have germline pathogenic variants of the BRCA 1, BRCA 2, and other genes associated with impaired DNA damage repair that is associated with an increased risk of breast, ovarian, and other cancers. Inhibitors of poly-ADP ribose polymerase (PARP) induce synthetic lethality in cancer cells harboring such pathogenic variants.Area coveredIn this review, the authors review the mechanisms of action, antitumor activity, and adverse events associated with PARP inhibitors for the treatment of advanced breast cancer. Read More

View Article and Full-Text PDF
March 2021
Similar Publications
© 2021 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap