Optimizing dose and fractionation for stereotactic body radiation therapy. Normal tissue and tumor control effects with large dose per fraction.

Front Radiat Ther Oncol 2007 ;40:352-365

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Tex. , USA.

Stereotactic body radiation therapy (SBRT) is a potent noninvasive means of administering high-dose radiation to demarcated tumor deposits in extracranial locations. The treatments use image guidance and related treatment delivery technology for the purpose of escalating the radiation dose to the tumor itself with as little radiation dose to the surrounding normal tissue as possible. The local tumor control for SBRT has been higher than anything previously published for radiotherapy in treating typical carcinomas. In addition, the pattern, timing and severity of toxicity have been very different than what was seen with conventional radiotherapy. In this review, the clinical characteristics and outcomes of SBRT are presented in the context of their underlying mechanisms. While much of the material is unproven and speculative, it at least qualitatively searches for understanding as to the biological basis for the observed clinical effects. Hopefully, it will serve as a motivation for more sophisticated biological research into the effects of SBRT.

Download full-text PDF

Source
http://dx.doi.org/10.1159/000106046DOI Listing
September 2007
6 Reads

Publication Analysis

Top Keywords

body radiation
8
radiation therapy
8
tumor control
8
stereotactic body
8
normal tissue
8
radiation dose
8
radiation
5
addition pattern
4
pattern timing
4
carcinomas addition
4
typical carcinomas
4
timing severity
4
treating typical
4
toxicity conventional
4
review clinical
4
radiotherapy review
4
conventional radiotherapy
4
radiotherapy treating
4
severity toxicity
4
published radiotherapy
4

Similar Publications