Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics.

Authors:
Professor Nail Bulakbasi, MD
Professor Nail Bulakbasi, MD
University of Kyrenia Department of Radiology
Professor of Radiology
Neuroradiology
Kyrenia, KKTC | Turkey

Neuroradiology 2007 Oct 14;49(10):805-12. Epub 2007 Jul 14.

Department of Radiology, Military Medical Faculty, Gulhane Military Medical Academy, Etlik, 06018 Ankara, Turkey.

Introduction: We describe the magnetic resonance (MR) imaging characteristics of dysembryoplastic neuroepithelial tumors (DNT) and discuss their differential diagnosis.

Material And Methods: Proton MR spectroscopy (TE 30 and 136 ms), diffusion-weighted and perfusion images were retrospectively evaluated in 22 patients with pathologically proven DNT (17 male and 5 female, mean age 18.7 years) and 14 control subjects (10 male and 4 female, mean age 16.9 years). The results from the DNT patients and from the control subjects were compared using an independent sample t-test and the degree of correlation was tested by Pearson's correlation.

Results: All DNTs were solitary and in a supratentorial cortical or subcortical location (ten temporal, eight frontal and four parietal). They had low-signal on T1-weighted images and high-signal on T2-weighted images without a prominent mass effect. Additionally a cystic appearance (six patients, 27.3%), cortical dysplasia (six patients, 27.3%) and contrast enhancement (four patients, 18.2%) were also noted. No significant differences were detected in NAA/Cho, NAA/Cr, NAA/Cho+Cr or Cho/Cr ratios between DNT and normal brain. DNTs had a significantly higher mI/Cr ratio and apparent diffusion coefficient (ADC) values and lower cerebral blood values than normal parenchyma (P < 0.001). ADC had the highest correlation with the diagnosis of DNT (r = 0.996) followed by relative cerebral blood volume (rCBV) (r = -0.883) and mI/Cr ratio (r = 0.663).

Conclusion: Proton MR spectroscopy, diffusion-weighted and perfusion imaging characteristics of DNTs provide additional information to their MR imaging findings. The MR spectrum showing a slight increase in mI/Cr ratio, and higher ADC and lower rCBV values than normal parenchyma help to differentiate DNTs from other cortical tumors, which had higher rCBV and lower ADC values than DNTs.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00234-007-0263-8DOI Listing
October 2007
8 Reads
2 Citations
2.485 Impact Factor

Publication Analysis

Top Keywords

mi/cr ratio
12
proton spectroscopy
12
cerebral blood
8
normal parenchyma
8
diffusion-weighted perfusion
8
adc values
8
male female
8
patients 273%
8
control subjects
8
female age
8
imaging characteristics
8
values normal
8
dysembryoplastic neuroepithelial
8
neuroepithelial tumors
8
patients
5
dnts
5
dnt
5
cho/cr ratios
4
ratios dnt
4
182% differences
4

References

(Supplied by CrossRef)

C Daumas-Duport et al.
2000

C Daumas-Duport et al.
Neurosurgery 1988

R Stanescu Cosson et al.
J Neuroradiol 2001

C Fernandez et al.
AJNR Am J Neuroradiol 2003

KK Koeller et al.
AJNR Am J Neuroradiol 1992

H Guesmi et al.
Neurochirurgie 1999

BL Baisden et al.
Am J Surg Pathol 2001

P Cervera-Pierot et al.
Neurosurgery 1997

MC Lee et al.
Childs Nerv Syst 2006

C Raybaud et al.
Childs Nerv Syst 2006

CH Chan et al.
J Neurosurg 2006

Similar Publications