Impact of new diagnostic criteria of diabetes mellitus.

J Coll Physicians Surg Pak 2007 Jun;17(6):327-30

Department of Pathology, CMH, Dera Nawab Sahib Cantt (Ahmed Pur East).

Objective: To compare the frequency of diabetic individuals diagnosed by fasting plasma glucose (FPG) > or = 7.0 mmol/L with previous value i.e. > or = 7.8 mmol/L and to determine the diagnostic accuracy of FPG > or = 7.0 mmol/L.

Design: A cross-sectional study.

Place And Duration Of Study: The Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from April to July 2003.

Patients And Methods: FPG of 5250 subjects was checked to compare the frequency of diabetic subjects diagnosed by FPG > or = 7.0 mmol/L with > or = 7.8 mmol/L. Of them, 301 symptom-free subjects were subjected to 75 g Oral Glucose Tolerance Test (OGTT) and their 2 hours post glucose (2-h PG) challenge level was taken as "gold standard" to determine the diagnostic accuracy of FPG at > or = 7.0 mmol/L.

Results: By lowering the cut off point of FPG from 7.8 mmol/L to 7.0 mmol/L, the percentage of diagnosed diabetic subjects increased from 35% to 42%. Statistical analysis revealed a significant increase (p < 0.0001). FPG > or = 7.0 mmol/L had a diagnostic sensitivity of 70%, specificity 91%, the predictive value of positive and negative diagnosis was 84% and 80% respectively.

Conclusion: FPG at cut off point of >7.0 mmol/L, will greatly facilitate the early diagnosis of diabetes mellitus (DM). An early diagnosis can be further facilitated by a combination of FPG and 2-h PG estimation.

Download full-text PDF

Source
http://dx.doi.org/06.2007/JCPSP.327330DOI Listing
June 2007
40 Reads
2 Citations
0.320 Impact Factor

Publication Analysis

Top Keywords

fpg mmol/l
16
fpg
9
mmol/l mmol/l
8
diagnostic accuracy
8
frequency diabetic
8
early diagnosis
8
mmol/l
8
accuracy fpg
8
determine diagnostic
8
compare frequency
8
diabetic subjects
8
diabetes mellitus
8
cut point
8
symptom-free subjects
4
84% 80%
4
july 2003patients
4
increase 00001
4
301 symptom-free
4
subjects subjected
4
42% statistical
4

Similar Publications