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Environ Toxicol Pharmacol 2021 Apr 13:103658. Epub 2021 Apr 13.

Institute of environment and health, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, 518055, China. Electronic address:

Human renal epithelial (HK-2) cells were treated with PM (50 µg/mL) from Shenzhen and Taiyuan, proteomics and bioinformatics were used to screen the differentially expressed proteins (DEPs). A total of 577 DEPs were screened after HK-2 cells exposed to Shenzhen PM, of which 426 were up-regulated and 151 were down-regulated. A total of 1250 DEPs were screened in HK-2 cells after exposure to Taiyuan PM, of which 488 were up-regulated and 185 were down-regulated. Read More

Exp Gerontol 2021 Apr 13:111338. Epub 2021 Apr 13.

Departments of Orthopaedics, University of Maryland School of Medicine, USA; Department of Physiology, University of Maryland School of Medicine, USA. Electronic address:

Mechanical forces are conducted through myofibers and into nuclei to regulate muscle development, hypertrophy, and homeostasis. We hypothesized that nuclei in aged muscle have changes in the nuclear envelope and associated proteins, resulting in altered markers of mechano-signaling.

Methods: YAP/TAZ protein expression and gene expression of downstream targets, Ankrd1 and Cyr61, were evaluated as mechanotransduction indicators. Read More

Front Endocrinol (Lausanne) 2021 22;12:598656. Epub 2021 Mar 22.

Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, China.

Pheochromocytoma, as a neuroendocrine tumor with the highest genetic correlation in all types of tumors, has attracted extensive attention. Von Hipper Lindau (VHL) has the highest mutation frequency among the genes associated with pheochromocytoma. However, the effect of VHL on the proteome of pheochromocytoma remains to be explored. Read More

BMC Mol Cell Biol 2021 Apr 7;22(1):21. Epub 2021 Apr 7.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, 226001, People's Republic of China.

Background: Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, SCs de-differentiate and reprogram to gain the ability to repair nerves. Read More

Front Oncol 2021 18;11:624421. Epub 2021 Mar 18.

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.

Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. PTC is typically curable with an excellent survival rate; however, some patients experience disease recurrence or death. This study aimed to discover potential key genes and signaling pathways of PTC, which could provide new insights for thyroid lesions. Read More