AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families.

Eur J Epidemiol 2007 8;22(8):527-32. Epub 2007 Jun 8.

Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China.

Purpose: To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation.

Methods: A total of 665 subjects from 157 Caucasian nuclear families were genotyped at the AHSG NlaIII, SacI sites. The association and linkage between the single SNP markers and haplotypes constructed by two markers in this gene and BMDs at the spine and hip were determined by using quantitative transmission disequilibrium test (QTDT).

Results: Significant within-family associations were obtained for spine BMD at both of studied markers (P = 0.036 and 0.005 at the NlaIII and SacI sites, respectively). Significant (P = 0.008 at the NlaIII locus) (P = 0.004 at the SacI locus) total associations at spine BMD were detected. Haplotype analyses confirmed those within-family and total association.

Conclusions: These data suggest the polymorphisms in the AHSG gene may have effects on BMD variation in Caucasian population.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10654-007-9140-3DOI Listing
November 2007
4 Reads

Publication Analysis

Top Keywords

ahsg gene
12
nlaiii saci
8
caucasian nuclear
8
mineral density
8
associations spine
8
bone mineral
8
saci sites
8
nuclear families
8
spine bmd
8
transmission disequilibrium
4
quantitative transmission
4
disequilibrium test
4
within-family associations
4
studied markers
4
bmd studied
4
determined quantitative
4
qtdtresults within-family
4
test qtdtresults
4
bmds spine
4
markers haplotypes
4

References

(Supplied by CrossRef)

G Jones et al.
Osteoporos Int 1994

RR Recker et al.
Endocrine 2002

C Binkert et al.
J Biol Chem 1999

L Kalabay et al.
Eur J Endocrinol 2002

L Audi et al.
Horm Res 1999

JE Eichner et al.
Calcif Tissue Int 1990

JE Eichner et al.
Genet Epidemiol 1992

IR Dickson et al.
Bone Miner 1994

JM Zmuda et al.
Calcif Tissue Int 1998

XH Liu et al.
Calcif Tissue Int 2003

N Risch et al.
Science 1996

Similar Publications