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Am J Ophthalmol 2021 Feb 28. Epub 2021 Feb 28.

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; The Charles T Campbell Microbiology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

Purpose: To compare the outcomes of Pseudomonas aeruginosa keratitis (PAK) in contact lens wearers (CLW) and non-contact lens wearers (non-CLW) and identify risk factors for poor visual acuity (VA) outcomes in each group.

Design: Retrospective cohort study.

Methods: Two hundred fourteen consecutive cases of PAK were included between January 2006 and December 2019. Read More

Radiat Res 2021 Mar 2. Epub 2021 Mar 2.

Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon, United Kingdom.

Epidemiological studies suggest an increased incidence and risk of cataract after low-dose (<2 Gy) ionizing radiation exposures. However, the biological mechanism(s) of this process are not fully understood. DNA damage and repair are thought to have a contributing role in radiation-induced cataractogenesis. Read More

Curr Eye Res 2021 Feb 25. Epub 2021 Feb 25.

Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Purpose: To explore the regulatory role of in the circRNA-miRNA-mRNA network using a cellular overexpression model (OE-) in lens epithelial cells.

Methods: The expression profiles of circRNAs, miRNAs and mRNAs were determined by RNA-seq, and a regulatory circRNA-miRNA-mRNA network was constructed via bioinformatics. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used for the functional annotation of circRNA host genes, differentially expressed (DE) genes, and miRNA targets. Read More

Autophagy 2021 Mar 3:1-17. Epub 2021 Mar 3.

Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.

In humans, (tudor domain containing 7) mutations lead to a syndrome combining congenital cataracts (CCs) and non-obstructive azoospermia (NOA), characterized by abnormal lens development and spermiogenesis. However, the molecular mechanism underlying TDRD7's functions in eye and testicular development are still largely unknown. Here, we show that the depletion of this gene in mice and humans resulted in the accumulation of autophagosomes and the disruption of macroautophagic/autophagic flux. Read More