[Immunological aspects of postoperative analgesia after abdominal hysterectomy].

Akush Ginekol (Sofiia) 2007 ;46(1):18-24

Background: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10. Ketoprofen inhibits cyclo-oxygenase activity and hence prostaglandin production.

Aim: We hypothesized that ketoprofen would affect release of IL-6 and IL-10 and modulate the immune response.

Method: We have evaluated 40 women, divided into four groups by the model of postoperative pain treatment: control group (only opioid) and experimental group (combination of i.v. ketoprofen and opioid). Serum IL-6 and IL-10 were measured before surgery, 24 and 72 hours after skin incision. Due to days in hospital we detected temperature and severe complications.

Results: IL-6 increased at 24h and normalized at 72h. In contrast IL-10 did not change significantly.

Conclusion: The two models of postoperative analgesia have both modulated immune response after abdominal hysterectomy in same way.

Download full-text PDF

Source
May 2007

Publication Analysis

Top Keywords

postoperative analgesia
8
il-6 il-10
8
days hospital
4
release il-6
4
ketoprofen opioid
4
il-10 modulate
4
72h contrast
4
modulate immune
4
combination ketoprofen
4
affect release
4
ketoprofen affect
4
prostaglandin productionaim
4
il-10 change
4
activity prostaglandin
4
severe complicationsresults
4
productionaim hypothesized
4
contrast il-10
4
hypothesized ketoprofen
4
immune responsemethod
4
responsemethod evaluated
4

Similar Publications