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J Med Microbiol 2022 Apr;71(4)

Research unit of Clinical Microbiology, University of Southern Denmark, Odense, Denmark.

Urinary tract infection (UTI) is one of the most common bacterial infections worldwide. Experimental models that accurately reflect the high susceptibility to UTI in humans have, however, been lacking. This situation has limited detailed research into the early bladder colonization by uropathogens and the early innate defence mechanisms elicited to prevent this. Read More

J Bacteriol 2022 May 4;204(5):e0000522. Epub 2022 Apr 4.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Haemophilus ducreyi causes cutaneous ulcers in children and the genital ulcer disease chancroid in adults. In humans, H. ducreyi is found in the anaerobic environment of an abscess; previous studies comparing bacterial gene expression levels in pustules with the inocula (∼4-h aerobic mid-log-phase cultures) identified several upregulated differentially expressed genes (DEGs) that are associated with anaerobic metabolism. Read More

Mycologia 2022 Mar-Apr;114(2):319-336. Epub 2022 Apr 1.

Department of Plant Sciences, University of the Free State, Bloemfontein 9300, South Africa.

Rust fungi are important plant pathogens and have been extensively studied on crops and other host plants worldwide. This study describes the heterecious life cycle of a rust fungus on (finger grass) and the species (large yellow bitter apple), (bitter apple), and (eggplant) in South Africa. Following field observations, inoculation studies involving telial isolates collected from plants produced spermogonia and aecia on , and . Read More

Cancer Immunol Immunother 2022 Feb 26. Epub 2022 Feb 26.

The Bloomberg-Kimmel Institute of Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Human gut microbial species found to associate with clinical responses to immune checkpoint inhibitors (ICIs) are often tested in mice using fecal microbiota transfer (FMT), wherein tumor responses in recipient mice may recapitulate human responses to ICI treatment. However, many FMT studies have reported only limited methodological description, details of murine cohorts, and statistical methods. To investigate the reproducibility and robustness of gut microbial species that impact ICI responses, we performed human to germ-free mouse FMT using fecal samples from patients with non-small cell lung cancer who had a pathological response or nonresponse after neoadjuvant ICI treatment. Read More

Rev Inst Med Trop Sao Paulo 2022 2;64:e9. Epub 2022 Feb 2.

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, LIM-06 - Imunopatologia da Esquistossomose, São Paulo, São Paulo, Brazil.

The Western-blotting technique was applied to identify antigenic fractions of excretory-secretory Toxocara canis antigen recognized by IgG antibodies throughout an experimental infection in mice challenged by different inocula. Mice were inoculated with 5, 50 and 500 embryonated eggs and serum samples were collected 15, 30, 60, 90 and 120 days post-infection. Serum samples were analyzed using an excretory-secretory Toxocara antigen. Read More