Cytogenetic evaluation of paracetamol effects in human lymphocytes culture.

Drug Chem Toxicol 2007 ;30(2):133-43

Institute for Genetic Engineering and Biotechnology, University of Sarajevo, Bosnia and Herzegovina.

Paracetamol is a common analgesic and antipyretic drug. It has been recognized as one of the most ordinary medications taken in overdoses. We examined the possible genotoxic effects of high paracetamol concentrations expected to occur after overdose. Paracetamol was added to the cultures at the beginning of the cultivation period. Separate cultures for three tested concentrations of paracetamol (50 microg/mL, 100 microg/mL, and 200 microg/mL) were set. Effects of paracetamol were evaluated by micronucleus cytokinesis-block assay, chromosome aberration analysis, and nuclear division index. Results demonstrate that paracetamol concentration of 200 microg/mL expresses certain genotoxic effects in human peripheral blood lymphocytes.

Download full-text PDF

Source
http://dx.doi.org/10.1080/01480540601186929DOI Listing
July 2007
10 Reads

Publication Analysis

Top Keywords

200 microg/ml
8
genotoxic effects
8
effects human
8
paracetamol
7
cultivation period
4
cultures cultivation
4
nuclear division
4
period separate
4
cultures three
4
separate cultures
4
analysis nuclear
4
overdose paracetamol
4
concentrations expected
4
cytokinesis-block assay
4
division demonstrate
4
expected occur
4
aberration analysis
4
occur overdose
4
paracetamol cultures
4
concentrations paracetamol
4

Similar Publications