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Curr Opin Pulm Med 2021 Apr 20. Epub 2021 Apr 20.

Maastricht University Campus Venlo, Venlo Department of Pharmacology and Toxicology, FHML, Maastricht University, Maastricht ILD Care Foundation Research Team, Ede Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Nieuwegein, The Netherlands.

Purpose Of The Review: Critical review on the notion that exposure to pesticides and herbicides lead to adverse effects in pulmonary health.

Recent Findings: The lung effects of several chemical classes of pesticides and herbicides is biologically plausible. However, the studies that describe the association between exposure and toxic lung effects have numerous limitations. Read More

Aquat Toxicol 2021 Apr 9;235:105827. Epub 2021 Apr 9.

Bielefeld University, Animal Ecology, Konsequenz 45, 33615 Bielefeld, Germany.

Toxicity tests using the model organism Caenorhabditis elegans have shown that exposure to small microplastics such as polystyrene (PS) beads lead to high body burdens and dietary restrictions that in turn inhibit reproduction. Pharyngeal pumping is the key mechanism of C. elegans for governing the uptake of food and other particles and can be easily monitored by determining the pumping rates. Read More

Free Radic Biol Med 2021 Apr 18. Epub 2021 Apr 18.

National Innovation and Attracting Talents "111" base, Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering college, Chongqing University, Chongqing, 400044, China. Electronic address:

Senescence is a cellular process that can be initiated by certain stressors such as UVA irradiation. The mechanism by which skin cells protect themselves from the UVA-induced senescence has not been fully investigated. Here, we demonstrate that Bach2 modulates the extent of UVA-induced photoaging through regulation of autophagy in skin fibroblasts. Read More

Neurochem Res 2021 Apr 21. Epub 2021 Apr 21.

Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.

Steroid receptor coactivator 1 (SRC-1) is one of the coactivators recruited by the nuclear receptors (NRs) when NRs are activated by steroid hormones, such as glucocorticoid. SRC-1 is abundant in hippocampus and hypothalamus and is also related to some major risk factors for depression, implicated by its reduced expression after stress and its effect on hypothalamus-pituitary-adrenal gland axis function. However, whether SRC-1 is involved in the formation of depression remains unclear. Read More

Vestn Oftalmol 2021 ;137(2):5-11

Institute of General Pathology and Pathophysiology, Moscow, Russia.

The gene encoding the cone-rod homeobox protein is a specific photoreceptor transcription factor crucial for retinal function. Persons temporarily residing in the Arctic zone during the polar summer may suffer from disturbances associated with extremely high ambient illumination. These environmental changes are mediated by retinal photoreceptors; therefore, it is important to study the expression of retinal genes in order to assess individual capacities of sensory adaptation to polar day conditions. Read More