Influence of age of mice on the susceptibility to murine schistosomiasis infection.

Authors:
Emmanuel O Wango
Emmanuel O Wango
Princeton University
United States
Kiio Kithome
Kiio Kithome
Institute of Primate Research
Nairobi | Kenya
Simon Kiarie
Simon Kiarie
University of Cambridge
United Kingdom
Moses Limo
Moses Limo
Institute of Primate Research

Afr J Health Sci 2006 Jan-Jun;13(1-2):47-54

Institute of Primate Research, Karen, Nairobi, Kenya.

Intensity of human schistosomiasis infection increases with age, a peak being attained at early puberty. Hormones could be involved in the age-related changes in susceptibility to schistosomiasis. Male BALB / c mice were infected with Schistosoma mansoni either before or after puberty and worm numbers, cellular immune responses, hormonal levels and pathology analysed. Pre-puberty infected mice had a significantly higher number of adult worms (p < 0.05), more severe granulomas, higher mortality rate and higher proliferative responses as compared to post-puberty infected mice. Levels of the hormones were lower in the pre-puberty infected mice as compared to the post-puberty group early in the infection. Plasma levels of testosterone and luteinizing hormones decreased significantly (p < 0.05) in infected mice when compared to controls. Susceptibility to S. mansoni in male BALB / c mice seems to be influenced by levels of testosterone and luteinizing hormone at infection. Albeit, an infection with S. mansoni seems to lower the hormonal levels.

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December 2008
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