Chilblain-like leukemia cutis.

Pediatr Dermatol 2007 Jan-Feb;24(1):38-41

Department of Dermatology, Queen's Medical Centre, University Hospital Nottingham NHS Trust, Nottingham, UK.

We present a 6-year-old girl with an 8-month history of fluctuating chilblain-like lesions on the toes. A full blood count showed slight thrombocytopenia and monocytosis. A skin biopsy specimen showed a dense perivascular and superficial dermal cellular infiltrate which was CD3(-), CD43(+), and lysosyme + on immunocytochemistry, suggesting a monocytic origin. Juvenile myelomonocytic leukemia was diagnosed after a bone marrow biopsy and spontaneous marrow colony growth in culture.

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http://dx.doi.org/10.1111/j.1525-1470.2007.00330.xDOI Listing
May 2007
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