J Arthroplasty 2007 Feb;22(2):235-40
Department of Orthopedic Surgery, University of Zurich, Balgrist, Switzerland.
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Clin Cancer Res 2018 Oct 29. Epub 2018 Oct 29.
Medicine, Memorial Sloan-Kettering Cancer Center and Weill Medical College at Cornell University.
Purpose: Prior molecular profiling of hepatocellular carcinoma (HCC) has identified actionable findings that may have a role in guiding therapeutic decision-making and clinical trial enrollment. We implemented prospective next-generation sequencing (NGS) in the clinic to determine whether such analyses provide predictive and/or prognostic information for HCC patients treated with contemporary systemic therapies.
Methods: Matched tumor/normal DNA from HCC patients (N=127) were analyzed using a hybridization capture-based, NGS assay designed to target 341 or more cancer-associated genes. Read More
J Cell Biochem 2018 Sep 26;119(9):7865-7872. Epub 2018 Jun 26.
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Systemic lupus erythematosus (SLE) concurs with excessive uncontrolled inflammatory immune responses that lead to the loss of immune tolerance. Dendritic cells (DCs) are important and determinant immune cells that regulate immune responses. Tolerogenic DCs with regulatory markers and cytokines could induce regulatory immune cells and responses. Read More
Chem Biodivers 2018 Aug 21;15(8):e1800045. Epub 2018 Jul 21.
Medical Research Department, National Institute of Occupational Safety and Health, 156 - EL Hegas Street, Cairo-, 11351, Egypt.
Breast cancer constitutes the second most prevalent cancer in Egypt, the problem needs more trends in treatment and treatment development either by regimen modification or introducing new drugs, and the main objective of this study is to screen the effects of the aqueous ethanol herbal extract of Luffa cylindrica leaves on different types of breast cancer cell lines representing different molecular subtypes of the disease. The major active constituents of the extract were tentatively identified by LC/MS which revealed the presence of phenolic compound derivatives and saponin that may be responsible in part for the activity of the extract. The emphasis was laid on the main apoptotic pathways as well as the extract effect on the normal cell line. Read More
Geriatrics (Basel) 2018 Jun 4;3(2). Epub 2018 Apr 4.
Department of Geriatrics and Department of Complementary and Alternative Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
In 2010, approximately 79 million Americans had prediabetes and about 50 percent of those individuals were 65 years and older. The most effective diabetes prevention method in prediabetic adults is lifestyle modification. However, despite the benefits of lifestyle change, diabetes prevalence continues to increase. Read More
Mutat Res Rev Mutat Res 2015 Apr-Jun;764:31-42. Epub 2015 Jan 25.
Superfund Research Program, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA. Electronic address:
Characterizing variability in the extent and nature of responses to environmental exposures is a critical aspect of human health risk assessment. Chemical toxicants act by many different mechanisms, however, and the genes involved in adverse outcome pathways (AOPs) and AOP networks are not yet characterized. Functional genomic approaches can reveal both toxicity pathways and susceptibility genes, through knockdown or knockout of all non-essential genes in a cell of interest, and identification of genes associated with a toxicity phenotype following toxicant exposure. Read More