Effects of a novel tripeptide on neurological outcomes after spinal cord injury.

Authors:
Sunil M John
Sunil M John
Robarts Research Institute
Feng Bao
Feng Bao
Robarts Research Institute
Canada
Yuhua Chen
Yuhua Chen
Robarts Research Institute
Canada
Ronald D Mathison
Ronald D Mathison
University of Calgary
Canada
Lynne C Weaver
Lynne C Weaver
Robarts Research Institute
Canada

Neuroreport 2006 Nov;17(17):1793-6

Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada.

A biologically active tripeptide [phenylalanine glutamate glycine (feG)] derived from the submandibular gland has anti-inflammatory actions. We have shown that intravenous treatment with feG after spinal cord injury decreases the intraspinal infiltration of leukocytes and associated oxidative damage within 72 h after injury. The present study assessed effects of this treatment on chronic neurological outcomes after clip-compression spinal cord injury at the 12th thoracic segment. Locomotor scores of feG-treated rats were significantly higher than those of controls at 7 weeks after spinal cord injury. Treated rats had significantly less hind paw mechanical allodynia than controls at this time. In conclusion, the anti-inflammatory and anti-oxidative actions of feG treatment correlate with improved neurological outcomes after spinal cord injury.

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November 2006
43 Reads

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