Radiation dose-rate effects, endogenous DNA damage, and signaling resonance.

Proc Natl Acad Sci U S A 2006 Nov 8;103(47):17874-9. Epub 2006 Nov 8.

The Sally Balin Medical Center, Media, PA 19063, USA.

We previously concluded, from our analysis of the published data of other investigators, that the yield of germ-line and somatic mutations after exposure to ionizing radiation is parabolically related to the logarithm of the dose-rate at which a given dose is administered. Here we show that other data reveal a similarly parabolic relationship for other ionizing radiation-associated phenomena, namely, genetic recombination, chromosomal translocation, cell inactivation and lethality, and human leukemogenesis. Furthermore, the minima for all effects fall in a relatively narrow range of the dose-rate logarithms. Because the only mechanism common to all of these phenomena is the double-strand break (DSB) in DNA, we refer to our previous analysis of the endogenous production of DSBs, from which we concluded that approximately 50 endogenous DSBs occur per cell cycle, although most are repaired without error. Comparison then reveals that their rate of production falls within the range of minima for the several end points pursuant to radiation-induced DSBs. We conclude that the results reflect a physiological principle whereby signals originating from induced DSBs elicit responses of maximal effectiveness when they are produced at a rate near that of the production of endogenous DSBs. We refer to this principle as "signaling resonance."

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http://dx.doi.org/10.1073/pnas.0607995103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693840PMC
November 2006

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References

(Supplied by CrossRef)

PNAS 2000

PNAS 2003

Lyon et al.
Nature: New biology 1972

Russell et al.
PNAS 1982

Russell et al.
PNAS 1982

Furuno-Fukushi et al.
Radiation research 1988

Kiefer et al.
Radiation research 1988

Pomerantseva et al.
Mutation Research 1984

Steel et al.
Physics in medicine and biology 1996

Mitchell et al.
Radiation research 1979

DeWeese et al.
The Journal of urology 1998

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