Heart 2007 Feb 7;93(2):172-6. Epub 2006 Nov 7.
Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK.
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Heart 2006 Mar 15;92(3):307-10. Epub 2005 Sep 15.
Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee, UK.
Objective: To examine whether the efficiency and equity of cardiovascular risk scores that identify patients at high risk for preventive interventions are compromised by omitting social deprivation, which contributes to risk.
Design: Cohort study.
Setting: The SHHEC (Scottish heart health extended cohort) study of random sample risk factor surveys across 25 districts of Scotland in 1984-87 and North Glasgow in 1989, 1992, and 1995. Read More
J Cardiovasc Med (Hagerstown) 2009 Feb;10(2):157-60
Clinical Pharmacology Unit, Centre for Cardiovascular Science, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
Background/objectives: Socioeconomic gradients exist in the prevalence of cardiovascular disease. This has prompted the development of risk scores such as ASSIGN and QRISK, which incorporate measures of deprivation, to address the issue of underprescribing of primary preventive medicines in the socially disadvantaged. The scores use area-based measures of deprivation rather than the socioeconomic status of the individual. Read More
BMJ 2007 Jul 5;335(7611):136. Epub 2007 Jul 5.
Tower Building, University Park, Nottingham NG2 7RD.
Objective: To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against the established Framingham cardiovascular disease algorithm and a newly developed Scottish score (ASSIGN).
Design: Prospective open cohort study using routinely collected data from general practice.
Setting: UK practices contributing to the QRESEARCH database. Read More
Br J Haematol 2009 Aug 22;146(4):442-6. Epub 2009 Jun 22.
Department of Medicine, Mount Sinai Medical School, New York, NY, USA.
Plasma fibrinogen is an established risk factor for cardiovascular disease (CVD), but it has not been established whether it adds predictive value to risk scores. In the Scottish Heart Health Extended Cohort Study, we measured plasma fibrinogen in 13 060 men and women, aged 30-74 years, initially free of CVD. After follow-up for a median of 19. Read More