fMRI study of problem-solving after severe traumatic brain injury.

Brain Inj 2006 Sep;20(10):1019-28

INSERM U 483, Paris, France.

Objective: To assess the cerebral correlates of the dysexecutive syndrome after diffuse severe traumatic brain injury (TBI).

Methods: Ten patients with sub-acute/chronic severe TBI without detectable focal cortical contusion and 11 matched healthy subjects were included in a parametric fMRI study using a planning task, the Tower of London.

Results: Brain activation in the left Dorsolateral Pre-frontal Cortex (DLPFC) and the Anterior Cingulate Cortex (ACC) was closely related to performance. Patients with TBI who performed the task efficiently showed, like healthy controls who obtained a similar pattern of performance, a large activation in the left DLPFC and a small activation in the ACC. In contrast, poor performance was associated with a reduced activation in these both regions.

Conclusion: Problem-solving deficits after severe diffuse TBI could be related to an impaired activation of the DLPFC and of the ACC.

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http://dx.doi.org/10.1080/02699050600664384DOI Listing
September 2006
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References

(Supplied by CrossRef)

Levin HS et al.
Brain Injury 2003

Azouvi P et al.
Current Opinion in Neurology 2000

Jenkins A et al.
The Lancet 1986

Scheid R et al.
American Journal of Neuroradiology 2003

Vilkki J et al.
Neuropsychologia 1992

Fontaine A et al.
Neurology 1999

Fan J et al.
Proceedings of the National Academy of Sciences (USA) 2003

Dreher J-C et al.
Cerebral Cortex 2003

Mariko O et al.
Neuroimage 2003

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