Managing the cognitive effects of brain tumor radiation therapy.

Curr Treat Options Oncol 2006 Nov;7(6):517-23

Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Postoperative radiation therapy (RT), either alone or in combination with chemotherapy, is the mainstay of treatment for primary and/or metastatic brain tumors. The majority of patients with brain tumors will have significant symptoms of their disease and of RT that will have a negative impact on their quality of life and neurocognitive function. The symptoms of brain tumors depend on tumor location. Radiation-induced brain injury is a complex and dynamic process involving all cells in the brain, including endothelial and oligodendroglial cells, astrocytes, microglia, neurons, and neuronal stem cells. The symptoms of radiation-induced brain injury may be acute, subacute, or chronic, occurring hours, days, weeks, months, and even years after exposure to radiation, the pathogenesis of which is oxidative stress and inflammation. At present, there are no effective preventive approaches for radiation-induced brain injury. Rather, the management of radiation-induced fatigue, changes in mood, and cognitive dysfunction involves a multidisciplinary approach using pharmacologic, behavioral, and rehabilitative therapies. Given the prevalence of brain neoplasms and the high incidence of the radiation-induced symptom cluster and brain injury, clinical research to address these important clinical problems is critical.

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http://dx.doi.org/10.1007/s11864-006-0026-5DOI Listing
November 2006
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References

(Supplied by CrossRef)

EG Shaw et al.
2000

MJ Dodd et al.
J Natl Cancer Inst Monogr 2004

MJ Dodd et al.
Oncol Nurs Forum 2001

MA et al.
J Neuropsychiatry Clin Neurosci 1995

RK Mulhern et al.
J Clin Oncol 2004

J Butler et al.
Int J Radiat Oncol Biol Phys 2005

MA Weitzner et al.
Cancer 1995

SB Yellen et al.
J Pain Symptom Manage 1997

EC Halperin et al.
1994

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