Difference in susceptibility to activity-based anorexia in two inbred strains of mice.

Eur Neuropsychopharmacol 2007 Feb 2;17(3):199-205. Epub 2006 Jun 2.

Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, UK.

Food restricted rodents develop activity-based anorexia in the presence of a running wheel, characterised by increased physical activity, weight loss and decreased leptin levels. Here, we determined trait differences in the development of activity-based anorexia between C57BL/6J and DBA/2J inbred mouse lines previously reported as having low and high anxiety, respectively. C57BL/6J mice housed with running wheels and exposed to scheduled feeding reduced their wheel activity, in contrast to DBA/2J mice which exhibited increased behavioural activity under these conditions. Food restriction induced hypoleptinemia in both strains, but the decline in plasma leptin was stronger in DBA/2J mice and correlated with increased activity only in that strain. These data suggest that plasma leptin level dynamics rather than hypoleptinemia alone influences the development of activity-based anorexia and that recombinant inbred panels based on these progenitor lines offer opportunities for the identification of molecular determinants for anorexia nervosa related behavioural traits.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euroneuro.2006.04.007DOI Listing
February 2007
4 Reads

Publication Analysis

Top Keywords

activity-based anorexia
16
dba/2j mice
8
plasma leptin
8
development activity-based
8
anorexia
5
contrast dba/2j
4
increased behavioural
4
exhibited increased
4
mice exhibited
4
behavioural activity
4
conditions food
4
induced hypoleptinemia
4
hypoleptinemia strains
4
restriction induced
4
food restriction
4
activity contrast
4
activity conditions
4
feeding reduced
4
anxiety c57bl/6j
4
c57bl/6j mice
4

Similar Publications