A computational model of how an interaction between the thalamocortical and thalamic reticular neurons transforms the low-frequency oscillations of the globus pallidus.

Authors:
Arash Hadipour-Niktarash, MD
Arash Hadipour-Niktarash, MD
Neurologist, epileptologist
Neurology, Epilepsy
Denver, Colorado | United States

J Comput Neurosci 2006 Jun 22;20(3):299-320. Epub 2006 Apr 22.

Department of Biomedical Engineering, Laboratory for Computational Motor Control, Johns Hopkins School of Medicine, 720 Rutland Ave, 416, Traylor Building, Baltimore, MD 21205-2195, USA.

In Parkinson's disease, neurons of the internal segment of the globus pallidus (GPi) display the low-frequency tremor-related oscillations. These oscillatory activities are transmitted to the thalamic relay nuclei. Computer models of the interacting thalamocortical (TC) and thalamic reticular (RE) neurons were used to explore how the TC-RE network processes the low-frequency oscillations of the GPi neurons. The simulation results show that, by an interaction between the TC and RE neurons, the TC-RE network transforms a low-frequency oscillatory activity of the GPi neurons to a higher frequency of oscillatory activity of the TC neurons (the superharmonic frequency transformation). In addition to the interaction between the TC and RE neurons, the low-threshold calcium current in the RE and TC neurons and the hyperpolarization-activated cation current (I (h)) in the TC neurons have significant roles in the superharmonic frequency transformation property of the TC-RE network. The external globus pallidus (GPe) oscillatory activity, which is directly transmitted to the RE nucleus also displays a significant modulatory effect on the superharmonic frequency transformation property of the TC-RE network.

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http://dx.doi.org/10.1007/s10827-006-6673-5DOI Listing
June 2006
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References

(Supplied by CrossRef)

C Asanuma et al.
Exp. Brain Res. 1994

T Bal et al.
Neuron 1996

I Bar-Gad et al.
Curr. Opin. Neurobiol. 2001

M Bazhenov et al.
J. Neurophysiol. 1998

M Bazhenov et al.
Nature Neurosci. 1999

H Bergman et al.
J. Neurophysiol. 1994

H Bergman et al.
Mov. Disord. 2002

C Beurrier et al.
J. Neurosci. 1999

J Carr et al.
Parkinsonism and related disorders 2002

CL Cox et al.
J. Neurosci. 1999

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