Radiotherapy in the treatment of mucosal melanoma of the upper aerodigestive tract: analysis of 74 cases. A Rare Cancer Network study.

Authors:
Marco Krengli
Marco Krengli
University of Piemonte Orientale
Italy
Laura Masini
Laura Masini
University of Piemonte Orientale
Italy
Philippe Maingon
Philippe Maingon
Université Catholique de Louvain
Belgium
Abderrahim Zouhair
Abderrahim Zouhair
Centre Hospitalier Universitaire Vaudois
Switzerland
Enis Ozyar
Enis Ozyar
Hacettepe University
Turkey
Martine Roelandts
Martine Roelandts
Université Libre de Bruxelles (ULB)
Belgium

Int J Radiat Oncol Biol Phys 2006 Jul 2;65(3):751-9. Epub 2006 May 2.

Department of Radiation Oncology, University of Piemonte Orientale, Novara, Italy.

Purpose: To retrospectively analyze a series of mucosal melanoma of the upper aerodigestive tract to determine the prognostic factors and contribute to understanding the role of radiotherapy in the therapeutic strategy.

Methods And Materials: Seventy-four patients were analyzed. The most frequent locations were nasal and oral, in 31 patients (41.9%) and 12 patients (16.2%), respectively. Sixty-three patients (85.1%) were in Stage I, 5 (6.8%) in Stage II, and 6 (8.1%) in Stage III. Treatment consisted of surgery in 17 patients (23.0%), surgery and radiotherapy in 42 (56.8%), radiotherapy in 11 (14.9%), and chemo-immunotherapy in 4 (5.4%). Median follow-up was 20 months.

Results: Local control at 3 years was 57% after surgery alone and 71% after surgery and radiotherapy. Overall and disease-free survival rates, respectively, were 41% and 31% at 3 years and 14% and 22% at 10 years. After univariate analysis, female gender, melanosis, tumor size
Conclusions: Local control was improved by postoperative radiotherapy, despite survival being as poor as in other published series. Stage I and melanosis at diagnosis were the most favorable prognostic factors.

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http://dx.doi.org/10.1016/j.ijrobp.2006.01.016DOI Listing

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July 2006
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