Search our Database of Scientific Publications and Authors

I’m looking for a
    Radiotherapy in the treatment of mucosal melanoma of the upper aerodigestive tract: analysis of 74 cases. A Rare Cancer Network study.
    Int J Radiat Oncol Biol Phys 2006 Jul 2;65(3):751-9. Epub 2006 May 2.
    Department of Radiation Oncology, University of Piemonte Orientale, Novara, Italy.
    Purpose: To retrospectively analyze a series of mucosal melanoma of the upper aerodigestive tract to determine the prognostic factors and contribute to understanding the role of radiotherapy in the therapeutic strategy.

    Methods And Materials: Seventy-four patients were analyzed. The most frequent locations were nasal and oral, in 31 patients (41.9%) and 12 patients (16.2%), respectively. Sixty-three patients (85.1%) were in Stage I, 5 (6.8%) in Stage II, and 6 (8.1%) in Stage III. Treatment consisted of surgery in 17 patients (23.0%), surgery and radiotherapy in 42 (56.8%), radiotherapy in 11 (14.9%), and chemo-immunotherapy in 4 (5.4%). Median follow-up was 20 months.

    Results: Local control at 3 years was 57% after surgery alone and 71% after surgery and radiotherapy. Overall and disease-free survival rates, respectively, were 41% and 31% at 3 years and 14% and 22% at 10 years. After univariate analysis, female gender, melanosis, tumor size
    Conclusions: Local control was improved by postoperative radiotherapy, despite survival being as poor as in other published series. Stage I and melanosis at diagnosis were the most favorable prognostic factors.

    Similar Publications

    Radiotherapy after surgical resection for head and neck mucosal melanoma.
    Am J Clin Oncol 2010 Jun;33(3):281-5
    Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10065, USA.
    Objectives: To present our single-institution experience with postoperative radiotherapy for mucosal melanoma of the head and neck.

    Methods: Between 1992 and 2007, 27 patients with mucosal melanoma of the head and neck underwent surgical resection followed by postoperative radiotherapy. Median age was 68 years (range: 45-89 years). Read More
    Postoperative radiotherapy for primary mucosal melanoma of the head and neck.
    Cancer 2005 Jan;103(2):313-9
    Department of Otorhinolaryngology/Head and Neck Surgery, Institut Gustave-Roussy, Villejuif, France.
    Background: Primary head and neck mucosal melanoma (HNMM) has a poor prognosis with a low local control rate and frequent distant metastases. The objective of the current study was to determine the impact of postoperative radiotherapy on local control and survival.

    Methods: One hundred forty-two patients with primary HNMM treated between 1979 and 1997 were reviewed. Read More
    Head and neck mucosal melanoma.
    Am J Clin Oncol 2005 Dec;28(6):626-30
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
    Purpose: The purpose of this article is to discuss the optimal treatment and outcomes for head and neck mucosal melanoma.

    Methods: Review the pertinent literature.

    Results: Head and neck mucosal melanoma is a rare entity comprising less than 1% for all Western melanomas. Read More
    A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan.
    Int J Radiat Oncol Biol Phys 2004 Jun;59(2):495-500
    Northern Japanese Radiation Therapy Oncology Group, Department of Radiology, Yamagata City Hospital, Yamagata, Japan.
    Purpose: A multi-institutional retrospective study was performed in northern Japan to analyze the outcome of external radiotherapy as the definitive treatment modality for localized mucosal melanoma of the head and neck.

    Patients And Methods: Thirty-one patients with localized mucosal melanoma of the head and neck treated by external radiotherapy at nine institutions of the Northern Japan Radiation Therapy Oncology Group between 1980 and 1999 were enrolled in this study. Radiotherapy alone was performed in 21 patients, and the remaining 10 patients received postoperative radiotherapy for gross residual tumors. Read More