Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: implications for multiple sclerosis.

J Neurovirol 2006 Feb;12(1):65-71

Department of Neurology, Clinical Research Unit for Multiple Sclerosis and Neuroimmunology, Würzburg, Germany.

The multiple sclerosis-associated retrovirus (MSRV), originally identified in cell cultures from patients with multiple sclerosis (MS), is closely related to the human endogenous retrovirus family W (HERV-W). Recently, HERV-W gag and env protein expression was demonstrated in MS lesions in situ. Here, the authors show that HERV-W gag and env proteins are induced by herpes simplex virus type 1 (HSV-1) in neuronal and brain endothelial cells in vitro. The transactivation of HERV-W proteins by HSV-1 could enhance their potential oligodendrotoxic and immunopathogenic effects, representing a mechanism by which HSV-1, and possibly also other herpesviruses associated with MS, may be linked to the pathogenesis of this disease.

Download full-text PDF

Source
http://link.springer.com/10.1080/13550280600614973
Publisher Site
http://dx.doi.org/10.1080/13550280600614973DOI Listing
February 2006
5 Reads

Publication Analysis

Top Keywords

herv-w gag
8
gag env
8
virus type
8
endogenous retrovirus
8
multiple sclerosis
8
herpes simplex
8
simplex virus
8
human endogenous
8
protein expression
8
representing mechanism
4
demonstrated lesions
4
vitro transactivation
4
expression demonstrated
4
env protein
4
family herv-w
4
hsv-1 enhance
4
sclerosis closely
4
hsv-1 herpesviruses
4
closely human
4
mechanism hsv-1
4

Altmetric Statistics

Similar Publications