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Bipolar Disord 2021 Feb 24. Epub 2021 Feb 24.

Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

We are interested in investigating whether melatonin receptor agonists (MEL-R-agonists), such as melatonin and ramelteon, benefit the treatment of bipolar mania. The recent double-blind randomized placebo-controlled trial (DBRPCT) reported that adjunctive melatonin administration was not superior to placebo in improving the mania scale scores of patients who received mood stabilizers or antipsychotics. Read More

Med Hypotheses 2021 Feb 13;149:110536. Epub 2021 Feb 13.

Laboratory on Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States. Electronic address:

Background: Mood stabilizers with disparate chemical structures are approved for treating bipolar disorder, but their mechanisms of action are not agreed on. However, when administered to unanesthetized rats at clinically relevant doses, they modulate neurotransmission involving arachidonic acid and brain activity of COX-2, which oxidizes arachidonic acid within the arachidonic acid metabolic cascade.

Hypothesis: Inhibiting COX-2 directly might enhance mood stabilizer effects in bipolar disorder patients. Read More

Expert Opin Pharmacother 2021 Feb 22. Epub 2021 Feb 22.

Mood Disorders Research Program, Depression Center Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine , Louisville, KY, USA 40202.

Introduction: : Research into the pharmacologic management of bipolar type I illness continues to progress.

Areas Covered: Randomized clinical trials performed with type I bipolar disorder in the years 2015 - August 2020 are reviewed. There are new indications for the use of cariprazine, for bipolar mania and depression, and a long-acting injectable formulation of aripiprazole has also been approved for relapse prevention in bipolar illness. Read More

Neuropsychiatr Dis Treat 2021 11;17:471-480. Epub 2021 Feb 11.

Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People's Republic of China.

Background: Mice with a deletion at exon 19 of the circadian locomotor output cycles Kaput gene () exhibit mania-like behavior and have been one of the most common animal models for bipolar disorder (BD). The predictive validity of the was investigated via studies using lithium previously. Determination of effects of other mood stabilizers on mouse would be helpful for better understanding of the mechanism underlined. Read More

Am Fam Physician 2021 Feb;103(4):227-239

Nashville Healthcare Center, Nashville, TN, USA.

Bipolar disorders are common, recurrent mental health conditions of variable severity that are difficult to diagnose. Affected individuals have higher rates of other mental health disorders, substance use disorders, and comorbid chronic medical illnesses. New diagnostic criteria and specifiers with attention on mixed features and anxious distress aid the physician in recognizing episode severity and prognosis. Read More