Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study.

J Hypertens 2006 Mar;24(3):471-7

Krankenhaus Barmherzige BrĂ¼der, Teaching Hospital Medical University Graz, Austria.

Objectives: Current evidence demonstrates that both genetic and environmental factors influence blood pressure. The sympathetic nervous system is a key player in blood pressure control and functional genetic variants of the beta-2 adrenergic receptor (B2AR) have been identified and implicated in the pathogenesis of hypertension. The present study aimed to determine the effects of common haplotypes of the B2AR gene upon blood pressure in the Caerphilly Prospective Study.

Design: Two thousand five hundred and twelve men (aged 45-59 years) participated in the study. We selected individuals in the upper (n = 347) and lower (n = 279) quintiles of the diastolic blood pressure distribution fixed at two time points [phase 2 (1984-88) or phase 3 (1989-93)] as cases and controls.

Methods: We analysed two functional polymorphisms (Arg16Gly and Gln27Glu) of B2AR and their haplotypes.

Results: We found a higher risk of hypertension in individuals homozygous for the Gln27 compared to those individuals homozygous for Glu27 [odds ratio (OR) = 1.94; 95% confidence interval (CI) = 1.34-2.81; P = 0.001]. Three haplotypes (Gly16Gln27, Gly16Glu27 and Arg16Gln27) were present in both quintile groups. Logistic regression analysis showed that haplotypes with a Gln27 allele (Gly16Gln27 and Arg16Gln27) conferred a significantly higher risk for hypertension than the Gly16Glu27 haplotype (OR = 1.55; 95% CI = 1.11-2.17, OR = 1.37; 95% CI = 1.04-1.81; P = 0.009 and P = 0.027, respectively). However, there was no evidence to support a statistically significant difference in odds ratios for the Gly16Gln27 and Arg16Gln27 haplotypes (P = 0.477), suggesting that it is the Gln27 allele alone, rather than any haplotype, which best explains the association.

Conclusions: In a prospectively studied Caucasian male cohort, high diastolic blood pressure was associated with B2AR haplotypes containing the pro-downregulatory Gln27 variant.

Download full-text PDF

Source
http://icmed.at/_science/_publications/_2000_2009/2006_Haplo
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/01.hjh.0000209983.28735.33DOI Listing
March 2006
5 Reads

Publication Analysis

Top Keywords

blood pressure
24
diastolic blood
12
pressure caerphilly
8
caerphilly prospective
8
gly16gln27 arg16gln27
8
higher risk
8
risk hypertension
8
individuals homozygous
8
high diastolic
8
gln27 allele
8
adrenergic receptor
8
beta-2 adrenergic
8
pressure
6
haplotypes
6
blood
6
compared individuals
4
glu27 [odds
4
homozygous glu27
4
gln27
4
pro-downregulatory gln27
4

Similar Publications