Safety of medications and hormones used in pediatric endocrinology: adrenal.

Pediatr Endocrinol Rev 2004 Nov;2 Suppl 1:134-45

Schneider Children's Hospital, New Hyde Park, NY 11040, and New York University School of Medicine, USA.

Glucocorticoids have been prescribed for several decades in treating adrenal insufficiency of various etiologies. These drugs are also heavily used in treating non-endocrine disease. This article will focus on adverse side effects encountered in the chronic use of different types of glucocorticoids in children and young adults with endocrine causes of adrenal insufficiency. Dosing guidelines are discussed with a view toward minimizing the common co-morbidities of growth suppression, excess weight gain, and osteopenia, among others. This article also discusses the use of several inhibitors of adrenal steroid biosynthesis and one glucocorticoid receptor antagonist for the medical treatment of Cushing syndrome.

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November 2004
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