Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association.

BMC Genet 2005 Dec 30;6 Suppl 1:S55. Epub 2005 Dec 30.

Department of Genetic Epidemiology, Georg-August University Göttingen, Humboldtallee 32, 37073 Göttingen, Germany.

For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads.

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Source
http://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156
Publisher Site
http://dx.doi.org/10.1186/1471-2156-6-S1-S55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866728PMC
December 2005

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