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Theriogenology 2021 Apr 2;168:33-40. Epub 2021 Apr 2.

Núcleo de Pesquisa e Conservação de Cervídeos, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista - NUPECCE/FCAV/UNESP, 14884-900, Jaboticabal, São Paulo, Brazil.

The genus Mazama stands out among the Neotropical deer due to their wide intra and interspecific karyotypic diversification, which is associated with an accentuated chromosomal fragility. There are reports of heterozygous Robertsonian translocation (RT) carriers in a free-range population of Mazama gouazoubira (brown brocket deer), as well as in captive animals of this and other species of the genus. To analyze possible negative impacts of heterozygous chromosome rearrangements on reproductive fitness of the carriers, we performed an analysis of sperm meiotic segregation in four brown brocket bucks, carriers of a rob(4;16), and compared the results with those of a normal buck. Read More

Front Oncol 2021 25;11:660955. Epub 2021 Mar 25.

Department of Gastroenterology, The Affiliated Taizhou Hospital, Wenzhou Medical University, Taizhou, China.

Objective: Dysregulation of feline leukemia virus subgroup C receptor 1(FLVCR1) expression has been investigated in several tumors. However, the expression and role of FLVCR1 in esophageal squamous cell carcinoma (ESCC) remain largely unknown.

Methods: FLVCR1 expression in tissues was measured by immunohistochemical staining (IHC). Read More

BMC Bioinformatics 2021 Apr 10;22(1):183. Epub 2021 Apr 10.

Department of Molecular and Cellular Biosciences, Rowan University, 201 Mullica Hill Rd, Glassboro, NJ, 08028, USA.

Background: The nucleus of eukaryotic cells spatially packages chromosomes into a hierarchical and distinct segregation that plays critical roles in maintaining transcription regulation. High-throughput methods of chromosome conformation capture, such as Hi-C, have revealed topologically associating domains (TADs) that are defined by biased chromatin interactions within them.

Results: We introduce a novel method, HiCKey, to decipher hierarchical TAD structures in Hi-C data and compare them across samples. Read More

Life Sci Alliance 2021 06 9;4(6). Epub 2021 Apr 9.

University of Rennes, EHESP, Inserm, Institut de Recherche en Santé, Environnement et Travail (Irset)-UMR_S 1085, Rennes, France

Environmental factors can induce detrimental consequences into adulthood life. In this study, we examined the epigenetic effects induced by in utero chlordecone (CD) exposure on human male cord blood as well as in blood-derived Ke-37 cell line. Genome-wide analysis of histone H3K4me3 distribution revealed that genes related to chromosome segregation, chromatin organization, and cell cycle have altered occupancy in their promoters. Read More

Semin Cell Dev Biol 2021 Apr 6. Epub 2021 Apr 6.

Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12237, United States; Rensselaer Polytechnic Institute, Troy, NY 12180, United States. Electronic address:

Mitotic spindle is a self-assembling macromolecular machine responsible for the faithful segregation of chromosomes during cell division. Assembly of the spindle is believed to be governed by the 'Search & Capture' (S&C) principle in which dynamic microtubules explore space in search of kinetochores while the latter capture microtubules and thus connect chromosomes to the spindle. Due to the stochastic nature of the encounters between kinetochores and microtubules, the time required for incorporating all chromosomes into the spindle is profoundly affected by geometric constraints, such as the size and shape of kinetochores as well as their distribution in space at the onset of spindle assembly. Read More