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J Fr Ophtalmol 2021 Feb 25. Epub 2021 Feb 25.

Faculty of Medicine, Bahcesehir University, 34734 Kadikoy, Istanbul, Turkey.

Purpose: To compare the efficacy and safety of subthreshold micropulse laser treatment (SML), standard-fluence photodynamic therapy (PDT) and low-fluence PDT in patients with chronic central serous chorioretinopathy (cCSC).

Methods: This retrospective study included 52 eyes of 46 patients with chronic CSC who were treated with 577nm SML (n=23), standard-fluence PDT (verteporfin 6mg/m and light energy 50J/cm) (n=13), or low-fluence PDT (verteporfin 6mg/m and light energy 25J/cm) (n=16). The mean changes in best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) parameters, including central retinal thickness (CRT), subretinal fluid (SRF) height, and ellipsoid zone (EZ) disruption, over the follow-up period were evaluated. Read More

Optom Vis Sci 2021 Feb 26. Epub 2021 Feb 26.

Illinois College of Optometry, Chicago, Illinois Southern California College of Optometry, Marshall B. Ketchum University, Fullerton, California

Significance: Although rarely seen, clinicians should closely monitor patients, especially pregnant patients with focal choroidal excavation (FCE), as it can convert between subtypes and has been linked to pachychoroidal disease and potential for vision loss.

Purpose: This study aimed to report a case of the conversion of conforming FCE to nonconforming FCE with spontaneous resolution in a pregnant female.

Case Report: A 35-year-old Indian woman presented with a slightly decreased vision in the right eye. Read More

Photodiagnosis Photodyn Ther 2021 Feb 22:102235. Epub 2021 Feb 22.

Department of Ophthalmology, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.

Purpose: To evaluate long-term changes in the foveal and parafoveal outer retina after half-dose photodynamic therapy (HD-PDT) in central serous chorioretinopathy (CSC).

Methods: Retrospective study including CSC patients submitted to HD-PDT. Best corrected visual acuity (BCVA) was evaluated. Read More

Medicine (Baltimore) 2021 Feb;100(7):e24790

Department of Ophthalmology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, P.R. China.

Rationale: Half-dose or reduced-fluence photodynamic therapy (PDT) with verteporfin has been well acknowledged to be the most effective and permanent treatment with very low rates of complications. However, we report a case of chronic central serous chorioretinopathy (CSC) who developed choroidal neovascularization (CNV) secondary to half-dose PDT within only 3 weeks. Such an occurrence following this short a course of treatment has not been reported previously. Read More

Medicine (Baltimore) 2021 Feb;100(7):e24789

Department of Ophthalmology, Nagoya University Graduate School of Medicine.

Rationale: Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease of unknown etiology. GPA affects multiple ocular tissues, most commonly the orbit, conjunctiva, cornea, and sclera. Retinal and choroidal manifestations are rare in GPA, but they often include choroidal neovascularization (CNV). Read More