[Experimental study of the lethal effects of steep pulsed electric field on cancer cells in BALB/c mice].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2005 Oct;22(5):896-900

Key Lab of High Voltage Engineering and Electrical New Technology, Ministry of Education, Chongqing University, Chongqing 400044, China.

This study was conducted to observe the lethal effects of steep pulsed electric field(SPEF) on the cancerous squamous cells in BALB/c mice. Female mice were inoculated with the solution of cervical cancer cells line. The tumor-bearing mice of the experiment group were exposed to SPEF. Then, the histomorphological changes were examined and compared between experiment group and control group. The histological and antitumor assay showed that SPEF could selectively injure tumor cells and inhibit cell proliferation. After treatment, pyknosis, karyoclasis and karyolysis of cancer cells were observed under light and electron mircroscope. More serious changes appeared some days later. These results indicate that SPEF have lethal effects on cervical cancer. It may prolong the survival period of tumor-bearing mice.

Download full-text PDF

Source
October 2005
7 Reads

Publication Analysis

Top Keywords

lethal effects
12
cancer cells
12
steep pulsed
8
tumor-bearing mice
8
experiment group
8
cells balb/c
8
effects steep
8
pulsed electric
8
cervical cancer
8
cells
5
days indicate
4
tumor cells
4
group exposed
4
exposed spef
4
spef histomorphological
4
appeared days
4
inoculated solution
4
observed light
4
injure tumor
4
cells tumor-bearing
4

Similar Publications