Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol: 38 cases (1996-2003).

Authors:
Rowan J Milner
Rowan J Milner
University of Florida
United States
Jamie Peyton
Jamie Peyton
University of California Davis
Kirsten Cooke
Kirsten Cooke
College of Veterinary Medicine
United States
Leslie E Fox
Leslie E Fox
College of Veterinary Medicine
United States
Alexander Gallagher
Alexander Gallagher
Virginia-Maryland Regional College of Veterinary Medicine
United States
Patti Gordon
Patti Gordon
University of Florida
United States

J Am Vet Med Assoc 2005 Oct;227(7):1118-22

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0126, USA.

Objective: To determine response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol.

Design: Retrospective study.

Animals: 38 cats with lymphoma.

Procedure: Medical records were reviewed, and information on age, sex, breed, FeLV and FIV infection status, anatomic form, clinical stage, and survival time was obtained. Immunophenotyping was not performed.

Results: Mean +/- SD age of the cats was 10.9 +/- 4.4 years. Overall median survival time was 210 days (interquartile range, 90 to 657 days), and overall duration of first remission was 156 days (interquartile range, 87 to 316 days). Age, sex, anatomic form, and clinical stage were not significantly associated with duration of first remission or survival time. Eighteen of the 38 (47%) cats had complete remission, 14 (37%) had partial remission, and 6 (16%) had no response. Duration of first remission was significantly longer for cats with complete remission (654 days) than for cats with partial remission (114 days). Median survival time for cats with complete remission (654 days) was significantly longer than median survival time for cats with partial remission (122 days) and for cats with no response (11 days).

Conclusions And Clinical Relevance: Results suggested that a high percentage of cats with lymphoma will respond to treatment with the University of Wisconsin-Madison chemotherapy protocol. Age, sex, anatomic form, and clinical stage were not significantly associated with duration of first response or survival time, but initial response to treatment was.
October 2005
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