Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.

Bioorg Med Chem Lett 2005 Dec 28;15(23):5202-6. Epub 2005 Sep 28.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA.

A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0501098
Publisher Site
http://dx.doi.org/10.1016/j.bmcl.2005.08.067DOI Listing
December 2005

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