Anti-atherogenic effect of insulin in vivo.

J Vasc Res 2005 Nov-Dec;42(6):455-62. Epub 2005 Sep 6.

Department of Physiology, University of Toronto, Toronto, Canada.

Metabolic syndrome is a risk factor for atherosclerosis and restenosis. In metabolic syndrome, insulin resistance coexists with hyperinsulinemia and hyperlipidemia. Hyperlipidemia has growth-promoting effects, whereas insulin has both growth-promoting and growth-inhibitory effects on vascular smooth muscle cells in vitro. The objective of this study was to investigate the effects of hyperlipidemia and hyperinsulinemia on vascular cell growth in vivo after arterial injury. Rats fed a low-fat diet were treated with either subcutaneous blank (LFC) or insulin (LFI) implants. Rats fed a high-fat diet also received blank (HFC) or insulin (HFI) implants. After 3 days, rats received balloon carotid injury, and 14 days later they were sacrificed to measure neointimal area and proliferation. Hyperinsulinemia was present in LFI and HFI and hyperlipidemia was present in HFC and HFI. Neointimal area was higher in HFC (0.153 +/- 0.009 mm(2), p < 0.05) but lower in LFI (0.098 +/- 0.005, p < 0.01) than LFC (0.127 +/- 0.005). In HFI (0.142 +/- 0.008, p < 0.05) neointimal area was not different from HFC or LFC. In conclusion, insulin reduced neointimal growth, but the effect of insulin was diminished by the high-fat diet. Thus, our results demonstrate an anti-atherogenic effect of insulin in vivo and suggest that in metabolic syndrome insulin resistance rather than hyperinsulinemia is the atherogenic risk factor.

Download full-text PDF

Source
http://dx.doi.org/10.1159/000088099DOI Listing
December 2005
32 Reads
2.901 Impact Factor

Publication Analysis

Top Keywords

neointimal area
12
metabolic syndrome
12
insulin
8
syndrome insulin
8
rats fed
8
+/- 0005
8
risk factor
8
insulin resistance
8
high-fat diet
8
insulin vivo
8
anti-atherogenic insulin
8
vivo metabolic
8
measure neointimal
4
higher hfc
4
area proliferation
4
neointimal
4
sacrificed measure
4
injury days
4
days sacrificed
4
area higher
4

The Emergence of Digital Opinion Leaders + Blood Cancer DOL Dashboard

This month we’ve pulled together a dashboard of 20 of the most impactful Digital Opinion Leaders (DOLs) related to Blood Cancers. Please take a live look at the DOL Board for this group of experts.

Read Article

Similar Publications