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Neth J Med 2018 05;76(4):190-193

Department of Internal Medicine, OLVG-West, Amsterdam, the Netherlands.

In the majority of hospitalised patients with hyponatraemia, syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the primary cause. Before considering SIADH, adrenal, thyroid and pituitary insufficiency should be ruled out. However, the evaluation of these contains potential pitfalls which could lead to incorrect diagnosing of SIADH. Read More

Am J Obstet Gynecol 1991 Nov;165(5 Pt 1):1330-3

Department of Internal Medicine A, Hadassah University Hospital, Jerusalem, Israel.

A 27-year-old woman experienced hemorrhagic shock after delivery. One week later she was seen in an obtunded state of consciousness. The results of laboratory evaluation were consistent with the syndrome of inappropriate antidiuretic hormone secretion caused by hypopituitarism. Read More

BMJ 2011 Mar 2;342:d405. Epub 2011 Mar 2.

Department of Clinical Chemistry, New Cross Hospital, Wolverhampton, UK.

J Pediatr Endocrinol Metab 2010 Jan-Feb;23(1-2):197-201

Department of Pediatrics, Lo-Tung St. Mary's Hospital, Taipei, Taiwan.

SIADH-like hyponatremia as the presenting manifestation of ACTH deficiency is rare in childhood. Here we report a 14 year-old girl who, after 8 years of GH replacement and subsequent treatment for subclinical secondary hypothyroidism, presented with confusion and disorientation due to severe hyponatremia. When her pituitary axis was re-assessed, she was diagnosed as having ACTH deficiency associated with multiple pituitary hormone deficiencies (MPHD) (including GH, FSH, LH, and subclinical TSH deficiencies). Read More