J Neurosci 2005 Aug;25(33):7682-6
Center for Biological Timing, Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA.
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J Neurosci 2007 Oct;27(44):12078-87
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA.
Circadian rhythmicity in the primary mammalian circadian pacemaker, the suprachiasmatic nucleus (SCN) of the hypothalamus, is maintained by transcriptional and translational feedback loops among circadian clock genes. Photic resetting of the SCN pacemaker involves induction of the clock genes Period1 (Per1) and Period2 (Per2) and communication among distinct cell populations. Gastrin-releasing peptide (GRP) is localized to the SCN ventral retinorecipient zone, from where it may communicate photic resetting signals within the SCN network. Read More
Brain Res 2006 Feb 17;1071(1):54-62. Epub 2006 Jan 17.
Department of Biological Sciences, Vanderbilt University, VU Station B, Box 35-1634, Nashville, TN 37235-1634, USA.
Neurons within the suprachiasmatic nucleus (SCN) comprise the master circadian pacemaker in mammals. These neurons exhibit circadian rhythms in spontaneous action potential frequency and in the transcription of core circadian clock genes, including Period1 (Per1). Targeted electrophysiological recordings from SCN neurons marked with a green fluorescent protein (GFP) reporter of Per1 gene transcription have previously indicated that K(+) currents are critically involved in the expression of neurophysiological rhythmicity. Read More
Cell Tissue Res 2002 Oct 3;310(1):85-92. Epub 2002 Aug 3.
Laboratory of Neurobiology of Rhythms, UMR 7518 CNRS/ULP, University of Strasbourg, 12, rue de l'université, 67000 Strasbourg, France.
In mammals, the suprachiasmatic nuclei (SCN) are the site of the master circadian pacemaker whose molecular core mechanism is based on interlocking transcriptional/translational feedback loops involving clock genes. Among clock genes, Per1 and Per2 are important for both the maintenance of circadian rhythmicity and entrainment to light cues. Several circadian rhythms (e. Read More
eNeuro 2017 Jul-Aug;4(4). Epub 2017 Aug 18.
Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093-0603.
Circadian rhythms of mammalian physiology and behavior are coordinated by the suprachiasmatic nucleus (SCN) in the hypothalamus. Within SCN neurons, various aspects of cell physiology exhibit circadian oscillations, including circadian clock gene expression, levels of intracellular Ca ([Ca]), and neuronal firing rate. [Ca] oscillates in SCN neurons even in the absence of neuronal firing. Read More