An efficient synthesis of gougerotin and related analogues using solid- and solution-phase methodology.

Org Lett 2005 Aug;7(16):3429-32

Ibis Therapeutics, a Division of Isis Pharmaceuticals, Inc., 1896 Rutherford Avenue, Carlsbad, CA 52008, USA.

The first solid-phase synthesis of the natural product gougerotin has been accomplished. The synthetic route is versatile and allows for diversification at position C-4 of the heterocycle, C-6' of the sugar ring, and both residues of the peptidic moiety at N-4' in a parallel fashion. [structure: see text]

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol0507322DOI Listing
August 2005
4 Reads

Publication Analysis

Top Keywords

diversification position
4
position c-4
4
c-4 heterocycle
4
heterocycle c-6'
4
allows diversification
4
route versatile
4
gougerotin accomplished
4
accomplished synthetic
4
synthetic route
4
c-6' sugar
4
sugar ring
4
parallel fashion
4
fashion [structure
4
[structure text]
4
n-4' parallel
4
moiety n-4'
4
ring residues
4
residues peptidic
4
peptidic moiety
4
product gougerotin
4

Altmetric Statistics

Similar Publications