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J Immunother Cancer 2022 May;10(5)

Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden

Background: Adenosine is a metabolite that suppresses antitumor immune response of T and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, AARs. While blockade of the AARs subtype effectively rescues lymphocyte activity, with four AAR antagonists currently in anticancer clinical trials, less is known for the therapeutic potential of the other AAR blockade within cancer immunotherapy. Recent studies suggest the formation of AAR/AAR dimers in tissues that coexpress the two receptor subtypes, where the AAR plays a dominant role, suggesting it as a promising target for cancer immunotherapy. Read More

J Ethnopharmacol 2022 May 14:115386. Epub 2022 May 14.

Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

Ethnopharmacological Relevance: Chronic prostatitis (CP) is a complex, intractable and prevalent urological disorder in men with no effective treatment. Guihuang formula (GHF) is a traditional Chinese medicine compound that is advantageous as a CP treatment, but its aetiology is poorly understood. Research and exploration of the mechanism of GHF will help the development of a potentially valuable drug for CP and provide deeper insight into CP. Read More

Bioorg Med Chem Lett 2022 May 14:128800. Epub 2022 May 14.

Department of Biotechnology, Faculty of Arts and Science, Mersin University, TR-33440, Mersin, Turkey; Mersin University Biotechnology Research and Application Center, Mersin University, TR-33440, Mersin, Turkey.

In this study, six new 1,4-disubstituted bis-1,2,3-triazole compounds, N,N'-(1,2-phenylene)bis(2-(4-R-1H-1,2,3-triazol-1-yl)acetamide), were synthesized with high yield (88-96%) by using click chemistry and their molecular structures were characterized by using NMR, FT-IR, HRMS and elemental analysis techniques. Previous studies suggest anti-inflammatory and analgesic activities for different 1,2,3-triazole derivatives and in the light of those studies we aimed to examine these novel derivatives immunomodulatory activities on the mammalian macrophages. Pro-inflammatory cytokines (TNF, IL6, GMCSF and IL12p40) secretion levels were tested in the presence of bis-1,2,3-triazole compounds when the macrophages were activated with LPS. Read More

Int Immunopharmacol 2022 May 14;108:108813. Epub 2022 May 14.

Guangdong Provincial Engineering Research Center of Molecular Imaging, Guangdong Provincial Key Laboratory of Biomedical Imaging, and Department of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; Lead Contact. Electronic address:

Immune-checkpoint blockade is widely studied for cancer therapy. Although the co-inhibitory receptor Programmed death-1(PD-1) blockade benefits some non-small cell lung cancer (NSCLC) patients, a large portion of NSCLC patients still fail to respond to this immunotherapy, and the underlying mechanism is unclear. Thus, a synergistic therapy to enhance the effect of PD-1 is urgently needed to improve the poor outcome of NSCLC patients. Read More

Arch Oral Biol 2022 May 12;140:105453. Epub 2022 May 12.

Unidad de Investigación Básica Oral (UIBO), Vicerrectoría de investigaciones, Facultad de Odontología, Universidad El Bosque, Bogotá, Colombia. Electronic address:

Objective: The aim was to determine the changes of inflammatory mediator expression in human macrophages stimulated with outer membrane vesicles purified from Porphyromonas gingivalis.

Design: outer membrane vesicles purified by ultracentrifugation from ATCC 33277 and W83 P. gingivalis strains were used for stimulating human macrophages and determine their inflammatory mediator expression changes. Read More