Preferential adhesion mediated by Hibris and Roughest regulates morphogenesis and patterning in the Drosophila eye.

Dev Cell 2005 Jun;8(6):925-35

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.

Cell adhesion is essential for morphogenesis; however, the mechanisms by which cell adhesion coordinates precisely regulated morphogenesis are poorly understood. Here we analyze the morphogenetic processes that organize the interommatidial precursor cells (IPCs) of the Drosophila pupal eye. We demonstrate that the Drosophila immunoglobulin superfamily members Hibris and Roughest are essential for IPC morphogenesis in the eye. The two loci are expressed in complementary cell types, and Hibris and Roughest proteins bind directly in vivo. Primary pigment cells employ Hibris to function as organizers in this process; IPCs minimize contacts with neighboring IPCs and utilize Roughest to maximize contacts with primaries. In addition, we provide evidence that interactions between Hibris and Roughest promote junction formation and that levels of Roughest in individual cells determine their capacity for competition. Our results demonstrate that preferential adhesion mediated by heterophilic interacting cell-adhesion molecules can create a precise pattern by minimizing surface free energy.

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S153458070500102
Publisher Site
http://dx.doi.org/10.1016/j.devcel.2005.03.011DOI Listing
June 2005
3 Reads

Publication Analysis

Top Keywords

hibris roughest
16
adhesion mediated
8
preferential adhesion
8
cell adhesion
8
roughest
6
hibris
5
function organizers
4
organizers process
4
hibris function
4
employ hibris
4
process ipcs
4
cells employ
4
pigment cells
4
neighboring ipcs
4
utilize roughest
4
roughest maximize
4
ipcs utilize
4
contacts neighboring
4
minimize contacts
4
ipcs minimize
4

Similar Publications